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Details for Product No. ABIN567796

Caspase 12 (CASP12) (N-Term), (AA 95-318) antibody

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Synonyms Caspase-12
»Alternatives N-Term, AA 95-318
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN567796
Quantity 0.1 mg
478.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Caspase-12 N-terminal fragment (aa 95-318).
Clone 14F4
Isotype IgG2a
Specificity This antibody reacts with Caspase-12 (~53 kDa) on Western blotting, Immunoprecipitation and Immunocytochemistry.
Purification Protein-G Agarose Chromatography of hybridoma supernatant.
Alternative Name Caspase-12
Background Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-beta, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid- beta and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form.
Alternate names: CASP-12, CASP12, Inactive caspase-12
Gene ID 100506742
NCBI Accession NP_001177945.1
UniProt Q6UXS9
Research Area Apoptosis/Necrosis
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50% Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Nakagawa, Zhu, Morishima et al.: "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta." in: Nature, Vol. 403, Issue 6765, pp. 98-103, 2000 (PubMed).

Nakagawa, Yuan: "Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis." in: The Journal of cell biology, Vol. 150, Issue 4, pp. 887-94, 2000 (PubMed).

Morishima, Nakanishi, Takenouchi et al.: "An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34287-94, 2002 (PubMed).

Alternatives for antigen "Caspase 12 (CASP12)", type "Antibodies"
Hosts (113), (6), (3)
Reactivities (84), (83), (64)
Applications (99), (48), (38), (37), (20), (4), (4), (4), (4), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (11), (7), (6), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)