Pan Actin antibody

Details for Product No. ABIN614804
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Dog (Canine), Chicken, Cat (Feline), Human, Mouse (Murine), Primate, Rabbit, Rat (Rattus)
(7), (6), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
(4), (4)
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(8), (6), (4), (3), (2), (2)
Pubmed 9 references available
Quantity 0.1 mg
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Catalog No. ABIN614804
357.50 $
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Immunogen SDS extracted protein fraction of Human myocardium.
Clone HHF35
Isotype IgG1
Specificity This antibody recognizes muscle-specific alpha and gamma actin (42 kDa) in various species. It stains skeletal, smooth and myocardial cells as well as myoepithelial cells and pericytes of small vessels. It is a widely used marker of muscle and muscle-derived cells.
Purification Protein-A Affinity Chromatography
Background Actin is a highly conserved ubiquitous globular protein (G-actin) that polymerizes to form fibrous F-actin microfilaments. In higher eucaryotes several actin isoforms have been identified, that fall into three classes. Alpha actin is a structural component of the contractile apparatus of muscle cells or muscle-derived cells. Beta actin and gamma actin play roles in regulation of cell motility in other cell types. Specific subcellular structures such as as stress fibers, focal adhesions, filopodia etc., are formed by involvement of actin cytoskeleton.
Cellular Localization: Cytoplasmic.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH~7.4 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
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anti-Pan Actin antibody anti-Pan Actin antibody
Background publications Miettinen: "Antibody specific to muscle actins in the diagnosis and classification of soft tissue tumors." in: The American journal of pathology, Vol. 130, Issue 1, pp. 205-15, 1988 (PubMed).

Schmidt, Cone, Haas et al.: "Diagnosis of rhabdomyosarcomas with HHF35, a monoclonal antibody directed against muscle actins." in: The American journal of pathology, Vol. 131, Issue 1, pp. 19-28, 1988 (PubMed).

Tsukada, Tippens, Gordon et al.: "HHF35, a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization." in: The American journal of pathology, Vol. 126, Issue 1, pp. 51-60, 1987 (PubMed).

Tsukada, McNutt, Ross et al.: "HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues." in: The American journal of pathology, Vol. 127, Issue 2, pp. 389-402, 1987 (PubMed).

de Sousa, Schwarzschild, de Araújo et al.: "Basal cell adenocarcinoma of the palate with squamous metaplasia." in: Journal of clinical pathology, Vol. 53, Issue 2, pp. 153-6, 2000 (PubMed).

Handharyani, Ochiai, Iwata et al.: "Immunohistochemical and ultrastructural study of ito cells (fat-storing cells) in response to extrahepatic bile duct ligation in broiler chickens." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 63, Issue 5, pp. 547-52, 2001 (PubMed).

Ijzer, Roskams, Molenbeek et al.: "Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver." in: Comparative hepatology, Vol. 5, pp. 7, 2006 (PubMed).

Matsuyama, Hisaoka, Hashimoto: "Angioleiomyoma: a clinicopathologic and immunohistochemical reappraisal with special reference to the correlation with myopericytoma." in: Human pathology, Vol. 38, Issue 4, pp. 645-51, 2007 (PubMed).

Matsuo, Susumu, Tsutsumi et al.: "Glomus tumor of the omentum: a case report." in: Journal of surgical oncology, Vol. 96, Issue 7, pp. 633-6, 2007 (PubMed).

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