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Details for Product No. ABIN638434

CD3 (CD3) antibody

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Synonyms CD3
Human, Primate
Clonality (Clone) Monoclonal ()
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
Pubmed 9 references available
Catalog no. ABIN638434
Quantity 0.1 mg
290.40 $   Plus shipping costs $45.00
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Availability Will be delivered in 4 to 5 Business Days
Immunogen human thymocytes followed by Sezary T cells
Clone UCHT1
Isotype IgG1
Specificity The antibody UCHT1 recognizes the CD3 antigen of the TCR/CD3 complex on mature human T cells. The UCHT1 antibody reacts with the epsilon chain of the CD3 complex. HLDA I, WS Code T 3, HLDA III, WS Code T 126, HLDA III, WS Code T 471, HLDA VI, WS Code T 6T-CD3.1
Endotoxin Level low endotoxin
Alternative Name CD3E
Gene ID 916
Research Area CD Antigens
Restrictions For Research Use only
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 micrometer filter sterilized. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.
Preservative Azide free
Storage 4 °C
Product cited in: Fisch, Malkovsky, Braakman et al.: "Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis." in: The Journal of experimental medicine, Vol. 171, Issue 5, pp. 1567-79, 1990 (PubMed).

Garson, Beverley, Coakham et al.: "Monoclonal antibodies against human T lymphocytes label Purkinje neurones of many species." in: Nature, Vol. 298, Issue 5872, pp. 375-7, 1982 (PubMed).

le Gouvello, Manceau, Sobel: "Serine 16 of stathmin as a cytosolic target for Ca2+/calmodulin-dependent kinase II after CD2 triggering of human T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 3, pp. 1113-22, 1998 (PubMed).

Torres, Alcover, Zapata et al.: "TCR dynamics in human mature T lymphocytes lacking CD3 gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 5947-55, 2003 (PubMed).

Arnett, Harrison, Wiley: "Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 46, pp. 16268-73, 2004 (PubMed).

Demedts, Brusselle, Vermaelen et al.: "Identification and characterization of human pulmonary dendritic cells." in: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, 2005 (PubMed).

Lin, Liu, Chen et al.: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Rieux-Laucat, Hivroz, Lim et al.: "Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency." in: The New England journal of medicine, Vol. 354, Issue 18, pp. 1913-21, 2006 (PubMed).

Siegers, Swamy, Fernández-Malavé et al.: "Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies." in: The Journal of experimental medicine, Vol. 204, Issue 11, pp. 2537-44, 2007 (PubMed).