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LAMP2 antibody (Lysosomal-Associated Membrane Protein 2)

Details for Product anti-LAMP2 Antibody No. ABIN638447, Supplier: Log in to see
Antigen
  • cd107b
  • lamp-2
  • lampb
  • LAMP2
  • lamp2
  • DKFZp459J126
  • LAMP-2
  • LGP-B
  • CD107b
  • Lamp-2
  • Lamp-2a
  • Lamp-2b
  • Lamp-2c
  • Mac3
  • LAMPB
  • LGP110
Reactivity
Human
241
176
32
24
19
6
Host
Mouse
153
117
115
1
Clonality (Clone)
Monoclonal ()
Conjugate
This LAMP2 antibody is un-conjugated
52
36
27
22
10
10
6
5
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
191
149
99
90
77
69
63
36
35
11
9
8
4
4
2
2
2
2
1
1
1
1
Supplier
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Immunogen Human PBMC
Clone H4B4
Isotype IgG1
Specificity The mouse monoclonal antibody H4B4 recognizes CD107b / LAMP-2, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.HLDA V., WS Code P007
No Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified from ascites by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Sterility 0.2 μm filtered
Alternative Name LAMP2 (LAMP2 Antibody Abstract)
Background CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.
Gene ID 3920
Research Area Stem Cells, Hematopoietic Progenitors, Autophagy, Metabolism, Organelles
Pathways
Application Notes Working concentrations should be determined by the investigator.I t is recommended that the user titrates the reagent for use in the particular testing system.

Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4.
Preservative Azide free
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8 °C. Do not use after expiration date stamped on vial label.
Product cited in: Meade, Wilson, Holmes et al.: "Proteolytic activation of the cytotoxic phenotype during human NK cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 803-13, 2009 (PubMed).

Thedrez, Harly, Morice et al.: "IL-21-mediated potentiation of antitumor cytolytic and proinflammatory responses of human V gamma 9V delta 2 T cells for adoptive immunotherapy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3423-31, 2009 (PubMed).

Apte, Baz, Groves et al.: "Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 45, pp. 17475-80, 2008 (PubMed).

Guia, Cognet, de Beaucoudrey et al.: "A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo." in: Blood, Vol. 111, Issue 10, pp. 5008-16, 2008 (PubMed).

Kannanganat, Ibegbu, Chennareddi et al.: "Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells." in: Journal of virology, Vol. 81, Issue 16, pp. 8468-76, 2007 (PubMed).

Palmer, Fernandez, Bisbing et al.: "Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells." in: The Journal of general virology, Vol. 88, Issue Pt 1, pp. 148-56, 2006 (PubMed).

Borgne-Sanchez, Dupont, Langonné et al.: "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells." in: Cell death and differentiation, Vol. 14, Issue 3, pp. 422-35, 2007 (PubMed).

Denzer, van Eijk, Kleijmeer et al.: "Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 3, pp. 1259-65, 2000 (PubMed).