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N-Acetyltransferase 8 (NAT8) (AA 110-138), (Center) antibody

Details for Product No. ABIN651148, Supplier: Log in to see
Antigen
  • Cml4
  • ATase2
  • CML1
  • GLA
  • Hcml1
  • TSC501
  • TSC510
  • 0610037O16Rik
Epitope
AA 110-138, Center
15
13
9
1
Reactivity
Human
30
4
4
Host
Rabbit
26
4
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
24
20
18
4
3
Supplier
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Immunogen This NAT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 AA from the Central region of human NAT8.
Clone RB25556
Isotype Ig
Specificity This NAT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 120-150 from the Central region of human NAT8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NAT8 (NAT8 Antibody Abstract)
Background This protein, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene.
Synonyms: Camello-like protein 1, Probable N-acetyltransferase 8,TSC501, GLA, CML1, NAT8
Molecular Weight 25619 DA
Gene ID 9027
UniProt Q9UHE5
Research Area Signaling, Cell Structure, Protein Modifications, Cell Cycle
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-N-Acetyltransferase 8 (NAT8) (AA 110-138), (Center) antibody (ABIN651148) Western blot analysis of NAT8 Antibody (Center) (ABIN651148) in ZR-75-1 cell line lys...
Immunohistochemistry (IHC) image for anti-N-Acetyltransferase 8 (NAT8) (AA 110-138), (Center) antibody (ABIN651148) NAT8 Antibody (Center) (ABIN651148) IHC analysis in formalin fixed and paraffin embed...
Product cited in: Ding, Dellisanti, Ko et al.: "The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides." in: The Journal of biological chemistry, Vol. 289, Issue 46, pp. 32044-55, 2014 (PubMed).

Ding, Ko, Pehar et al.: "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ?-secretase (BACE1) levels and A? generation." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8424-33, 2012 (PubMed).

Background publications Ko, Puglielli: "Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels." in: The Journal of biological chemistry, Vol. 284, Issue 4, pp. 2482-92, 2009 (PubMed).

Juhanson, Kepp, Org et al.: "N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study." in: BMC medical genetics, Vol. 9, pp. 25, 2008 (PubMed).

Barrios-Rodiles, Brown, Ozdamar et al.: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, 2005 (PubMed).