PAP Associated Domain Containing 4 (PAPD4) (N-Term), (AA 58-87) antibody

Details for Product No. ABIN651284
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Antigen
Synonyms GLD2, 8030446C20Rik, AI649009, GLD-2, Gld2, zgc:110560
Epitope
N-Term, AA 58-87
(9), (7), (2), (1)
Reactivity
Human, Hamster, Mouse (Murine)
(13), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(15)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(15), (7), (7), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN651284
291.50 $
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Immunogen This GLD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 AA from the N-terminal region of human GLD2.
Clone RB26128
Isotype Ig
Specificity This GLD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-95 amino acids from the N-terminal region of human GLD2.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GLD2
Background GLD2 is cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. GLD2 does not play a role in replication-dependent histone mRNA degradation.
Synonyms: Terminal uridylyltransferase 2, TUTase 2, PAP-associated domain-containing protein 4, Poly(A) RNA polymerase GLD2, hGLD-2,GLD2, PAPD4
Molecular Weight 56028 DA
Gene ID 167153
UniProt Q6PIY7
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-PAP Associated Domain Containing 4 (PAPD4) (N-Term), (AA 58-87) antibody (LEFT)Western blot analysis of GLD2 Antibody (N-term) (ABIN651284) in MCF-7 cell line lysates (35 µg/lane).GLD2 (arrow) was detected using the purified polyclonal antibody. (MIDDLE)Western blot analysis of GLD2 Antibody (N-term) (ABIN651284) in mouse heart tissue lysates (35 µg/lane).GLD2 (arrow) was detected using the purified polyclonal antibody. (RIGHT)Western blot analysis of GLD2 Antibody (N-term) (ABIN651284) in CHO cell line lysates (35 µg/lane).GLD2 (arrow) was detected using the purified polyclonal antibody.
anti-PAP Associated Domain Containing 4 (PAPD4) (N-Term), (AA 58-87) antibody (2) GLD2 Antibody (N-term) (ABIN651284) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Kwak, Wang, Ballantyne et al.: "Mammalian GLD-2 homologs are poly(A) polymerases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 13, pp. 4407-12, 2004 (PubMed).

Mullen, Marzluff: "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'." in: Genes & development, Vol. 22, Issue 1, pp. 50-65, 2008 (PubMed).

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