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Actin-Like 6B (ACTL6B) (N-Term), (AA 42-70) antibody

Details for Product No. ABIN651520
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Antigen
Synonyms ACTL6, BAF53B, Actl6, ArpNa, Baf53b, MGC110167, zgc:110167
Epitope
N-Term, AA 42-70
(7), (7), (1), (1), (1), (1)
Reactivity
Human
(19), (2), (2), (2)
Host
Rabbit
(18), (3), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(19), (11), (9), (8), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN651520
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This ACTL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 AA from the N-terminal region of human ACTL6B.
Clone RB26766
Isotype Ig
Specificity This ACTL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-80 amino acids from the N-terminal region of human ACTL6B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ACTL6B
Background ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila, the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
Synonyms: BRG1-associated factor 53B, BAF53B, ArpNalpha, Actin-related protein Baf53b, 53 kDa BRG1-associated factor B, Actin-like protein 6B,BAF53B, ACTL6, ACTL6B
Molecular Weight 46877  DA
Gene ID 51412
UniProt O94805, NP_057272.1
Research Area Translation Factors, Signaling, Chromatin, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Actin-Like 6B (ACTL6B) (N-Term), (AA 42-70) antibody ACTL6B Antibody (N-term) (ABIN651520) western blot analysis in NCI-H460,HepG2 cell line lysates (35 µg/lane). This demonstrates the ACTL6B antibody detected the ACTL6B protein (arrow).
anti-Actin-Like 6B (ACTL6B) (N-Term), (AA 42-70) antibody (2) ACTL6B Antibody (N-term) (ABIN651520) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-Actin-Like 6B (ACTL6B) (N-Term), (AA 42-70) antibody (3) ACTL6B Antibody (N-term) (ABIN651520) flow cytometric analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Olave, Wang, Xue et al.: "Identification of a polymorphic, neuron-specific chromatin remodeling complex." in: Genes & development, Vol. 16, Issue 19, pp. 2509-17, 2002 (PubMed).

Kuroda, Oma, Nishimori et al.: "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex." in: Biochemical and biophysical research communications, Vol. 299, Issue 2, pp. 328-34, 2002 (PubMed).

Oma, Nishimori, Harata: "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP." in: Biochemical and biophysical research communications, Vol. 301, Issue 2, pp. 521-8, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN651520
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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