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Eukaryotic Translation Initiation Factor 3, Subunit G (EIF3G) (AA 209-238), (Center) antibody

Details for Product No. ABIN651535, Supplier: Log in to see
Antigen
  • EIF3-P42
  • EIF3S4
  • eIF3-delta
  • eIF3-p44
  • 44kDa
  • D0Jmb4
  • Eif3s4
  • TU-189B2
  • p44
  • eif3s4
  • zgc:56553
  • eIF3g-A
  • eif3s4-A
  • eIF3g
  • eIF3-S4
  • An16g05260
  • AO090011000648
Epitope
AA 209-238, Center
15
14
13
9
4
4
3
3
2
2
2
2
2
1
1
1
Reactivity
Human
69
27
27
5
3
2
2
1
1
Host
Rabbit
61
6
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
51
31
22
17
11
8
7
6
1
1
Supplier
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Immunogen This EIF3G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 AA from the Central region of human EIF3G.
Clone RB26846
Isotype Ig
Specificity This EIF3G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-247 amino acids from the Central region of human EIF3G.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus),Xenopus laevis,Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name EIF3G (EIF3G Antibody Abstract)
Background Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.
Synonyms: eIF3 p42, eIF3 p44, Eukaryotic translation initiation factor 3 RNA-binding subunit, eIF-3 RNA-binding subunit, eIF-3-delta, Eukaryotic translation initiation factor 3 subunit 4, Eukaryotic translation initiation factor 3 subunit G, eIF3g,EIF3S4, EIF3G
Molecular Weight 35611 DA
Gene ID 8666
NCBI Accession NP_003746
UniProt O75821
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Signaling, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Eukaryotic Translation Initiation Factor 3, Subunit G (EIF3G) (AA 209-238), (Center) antibody (ABIN651535) EIF3G Antibody (Center) (ABIN651535) western blot analysis in K562 cell line lysates ...
Immunohistochemistry (IHC) image for anti-Eukaryotic Translation Initiation Factor 3, Subunit G (EIF3G) (AA 209-238), (Center) antibody (ABIN651535) EIF3G Antibody (Center) (ABIN651535) immunohistochemistry analysis in formalin fixed ...
Flow Cytometry (FACS) image for anti-Eukaryotic Translation Initiation Factor 3, Subunit G (EIF3G) (AA 209-238), (Center) antibody (ABIN651535) EIF3G Antibody (Center) (ABIN651535) flow cytometric analysis of K562 cells (bottom h...
Background publications Zhou, Sandercock, Fraser et al.: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, 2008 (PubMed).

Masutani, Sonenberg, Yokoyama et al.: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, 2007 (PubMed).