Importin 7 (IPO7) (N-Term), (AA 142-169) antibody

Details for Product No. ABIN651626
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Antigen
Epitope
N-Term, AA 142-169
(7), (6), (6), (3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(35), (14), (14), (14), (14), (12)
Host
Rabbit
(27), (7), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(25), (13), (12), (10), (7), (4), (2), (2)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN651626
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Immunogen This IPO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 AA from the N-terminal region of human IPO7.
Clone RB26876
Isotype Ig
Specificity This IPO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-179 amino acids from the N-terminal region of human IPO7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IPO7
Background The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
Synonyms: IPO7,RANBP7
Molecular Weight 119517 DA
Gene ID 10527
NCBI Accession NP_006382
UniProt O95373
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Importin 7 (IPO7) (N-Term), (AA 142-169) antibody IPO7 Antibody (N-term)(ABIN651626) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).
anti-Importin 7 (IPO7) (N-Term), (AA 142-169) antibody (2) IPO7 Antibody (N-term)(ABIN651626) western blot analysis in mouse NIH-3T3 cell line lysates (35 µg/lane). This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).
anti-Importin 7 (IPO7) (N-Term), (AA 142-169) antibody (3) IPO7 Antibody (N-term) (ABIN651626) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Görlich, Dabrowski, Bischoff et al.: "A novel class of RanGTP binding proteins." in: The Journal of cell biology, Vol. 138, Issue 1, pp. 65-80, 1997 (PubMed).

Jäkel, Görlich: "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells." in: The EMBO journal, Vol. 17, Issue 15, pp. 4491-502, 1998 (PubMed).

Paraskeva, Izaurralde, Bischoff et al.: "CRM1-mediated recycling of snurportin 1 to the cytoplasm." in: The Journal of cell biology, Vol. 145, Issue 2, pp. 255-64, 1999 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

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