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TPTEa (AA 42-74), (N-Term) antibody

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AA 42-74, N-Term
(10), (7), (1)
Clonality (Clone)
Polyclonal ()
(1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(9), (9), (7)
Pubmed 2 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This TPTEa antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-74 AA from the N-terminal region of human TPTEa.
Clone RB4973
Isotype Ig
Specificity This TPTEa antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51~80 amino acids from the N-terminal region of human TPTEa.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.
Molecular Weight 64307 DA
Gene ID 7179
UniProt P56180
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Neurology
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.47 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TPTEa (AA 42-74), (N-Term) antibody (ABIN652246) TPTEa Antibody (E57) (ABIN652246) western blot analysis in MDA-MB231 cell line lysate...
Immunohistochemistry (IHC) image for anti-TPTEa (AA 42-74), (N-Term) antibody (ABIN652246) TPTEa Antibody (N-term) (ABIN652246)immunohistochemistry analysis in formalin fixed a...
Background publications Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21. ..." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Chen, Rossier, Morris et al.: "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y." in: Human genetics, Vol. 105, Issue 5, pp. 399-409, 2000 (PubMed).

Catalog No. ABIN652246
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