Sorbin and SH3 Domain Containing 2 (Sorbs2) (N-Term), (AA 175-204) antibody

Details for Product No. ABIN652279
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Antigen
Synonyms Argbp2, mKIAA0777, A530071H08, 2010203O03Rik, 9430041O17Rik, ARGBP2, PRO0618, 9430041O17RIK, argbp2, pro0618, DKFZp468F1119
Epitope
N-Term, AA 175-204
(2), (1), (1), (1)
Reactivity
Human
(28), (24), (24), (24), (24), (12), (12), (12)
Host
Rabbit
(27), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(19), (10), (7), (7), (3), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN652279
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This ARGBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-204 AA from the N-terminal region of human ARGBP2.
Clone RB19714
Isotype Ig
Specificity This ARGBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182~212 amino acids from the N-terminal region of human ARGBP2.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ARGBP2
Background Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. ARGBP2 is the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology(SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.
Synonyms: Sorbin and SH3 domain-containing protein 2, Arg/Abl-interacting protein 2, ArgBP2, Sorbin, KIAA0777, ARGBP2, SORBS2
Molecular Weight 124108 DA
Gene ID 8470
UniProt O94875
Research Area Cancer, Cell Structure
Application Notes IF = 1:10-50, WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Sorbin and SH3 Domain Containing 2 (Sorbs2) (N-Term), (AA 175-204) antibody Western blot analysis of ARGBP2 Antibody (N-term) (ABIN652279) in MDA-MB231 cell line lysates (35 µg/lane). ARGBP2 (arrow) was detected using the purified polyclonal antibody.
anti-Sorbin and SH3 Domain Containing 2 (Sorbs2) (N-Term), (AA 175-204) antibody (2) Formalin-fixed and paraffin-embedded human colon carcinoma reacted with ARGBP2 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Sorbin and SH3 Domain Containing 2 (Sorbs2) (N-Term), (AA 175-204) antibody (3) Flow cytometric analysis of MDA-231 cells using ARGBP2 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Yuan, Kim, Kaneko et al.: "ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival." in: The Journal of biological chemistry, Vol. 280, Issue 22, pp. 21483-90, 2005 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Taieb, Roignot, André et al.: "ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity." in: Cancer research, Vol. 68, Issue 12, pp. 4588-96, 2008 (PubMed).

Hosts (27), (1)
Reactivities (28), (24), (24), (24), (24), (12), (12), (12)
Applications (19), (10), (7), (7), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (2), (1), (1), (1)
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