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phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (AA 513-541), (Center) antibody

Details for Product No. ABIN652449, Supplier: Log in to see
Antigen
  • PLA2G4A
  • pla2g4
  • CPLA2
  • PLA2G4
  • Pla2g4
  • cPLA2
  • cPLA2alpha
  • cPLA2-alpha
  • Pla2c
  • PLA2
  • PLA2G1B
Epitope
AA 513-541, Center
31
22
11
7
7
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
103
40
31
4
2
2
1
1
Host
Rabbit
82
15
8
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
6
5
4
3
3
3
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
79
57
21
15
15
13
6
5
4
3
3
2
1
Supplier
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Immunogen This PLA2G4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-541 AA from the Central region of human PLA2G4A.
Clone RB21320
Isotype Ig
Specificity This PLA2G4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520~549 amino acids from the Center region of human PLA2G4A.
Predicted Reactivity Chicken,Mouse (Murine),Rat (Rattus),Rabbit,Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PLA2G4A (PLA2G4A Antibody Abstract)
Background PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Synonyms: Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2, PLA2G4A
Molecular Weight 85211 DA
Gene ID 5321
UniProt P47712
Research Area Neurology
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (AA 513-541), (Center) antibody (ABIN652449) Western blot analysis of PLA2G4A Antibody (Center) (ABIN652449) in NCI-H460 cell line...
Immunohistochemistry (IHC) image for anti-phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (AA 513-541), (Center) antibody (ABIN652449) Formalin-fixed and paraffin-embedded human lung carcinoma with PLA2G4A Antibody (Cent...
Flow Cytometry (FACS) image for anti-phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (AA 513-541), (Center) antibody (ABIN652449) Flow cytometric analysis of NCI-H292 cells using PLA2G4A Antibody (Center)(bottom his...
Background publications Clark, Lin, Kriz et al.: "A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP." in: Cell, Vol. 65, Issue 6, pp. 1043-51, 1991 (PubMed).

Sharp, White, Chiou et al.: "Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 14850-3, 1991 (PubMed).