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Details for Product No. ABIN652514

BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143), (Center) antibody

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Synonyms C19orf62, MERIT40, NBA1, 5430437P03Rik, Merit40, c19orf62, merit40, nba1, C7H19orf62, zgc:100909
»Alternatives AA 116-143, Center
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 1 reference available
Catalog no. ABIN652514
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 AA from the Central region of human HSPC142.
Clone RB20468
Isotype Ig
Specificity This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122~152 amino acids from the Center region of human HSPC142
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HSPC142
Background Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
Synonyms: BRCA1-A complex subunit MERIT40, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex, HSPC142, NBA1, C19orf62, MERIT40
Molecular Weight 36560 DA
Gene ID 29086
UniProt Q9NWV8
Research Area Cancer, Neurology, Cell Structure
Application Notes Recommend dilutions: IHC : 1:50-100,WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Shao, Patterson-Fortin, Messick et al.: "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks." in: Genes & development, Vol. 23, Issue 6, pp. 740-54, 2009 (PubMed).

Alternatives for antigen "BRISC and BRCA1 A Complex Member 1 (BABAM1)", type "Antibodies"
Hosts (10), (1), (1)
Reactivities (11), (1), (1), (1), (1), (1)
Applications (11), (5), (4), (2), (1), (1), (1), (1)
Epitopes (5), (2), (1), (1), (1), (1), (1), (1), (1)