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BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) antibody

BABAM1 Reactivity: Human WB, IHC (p), FACS Host: Rabbit Polyclonal RB20468 unconjugated
Catalog No. ABIN652514
  • Target See all BRISC and BRCA1 A Complex Member 1 (BABAM1) Antibodies
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Binding Specificity
    • 10
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 116-143
    Reactivity
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 21
    • 4
    • 1
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Un-conjugated
    Application
    • 23
    • 16
    • 13
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Predicted Reactivity
    B, M, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the Central region of human HSPC142.
    Clone
    RB20468
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Alternative Name
    HSPC142 (BABAM1 Products)
    Synonyms
    merit40 antibody, nba1 antibody, zgc:100909 antibody, c19orf62 antibody, C19orf62 antibody, MERIT40 antibody, NBA1 antibody, C7H19orf62 antibody, 5430437P03Rik antibody, Merit40 antibody, BRISC and BRCA1 A complex member 1 antibody, BRISC and BRCA1 A complex member 1 L homeolog antibody, babam1 antibody, BABAM1 antibody, babam1.L antibody, Babam1 antibody
    Background
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
    Molecular Weight
    36560
    Gene ID
    29086
    NCBI Accession
    NP_001028721, NP_054892
    UniProt
    Q9NWV8
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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