Estrogen-Related Receptor alpha (ESRRA) (AA 131-159), (Center) antibody

Details for Product No. ABIN652575
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Antigen
Synonyms err1, erra, esrral, erralpha, nr3b1, MGC80854, ESRRA, esrl1, LOC100125507, ERRalpha, Err1, Estrra, Nr3b1, Errra, ERR1, ERRa, ESRL1, NR3B1, ESTRRA
Epitope
AA 131-159, Center
(11), (6), (6), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(66), (26), (23), (19), (19), (12)
Host
Rabbit
(64), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
(47), (16), (12), (10), (8), (7), (7), (6), (3), (3), (2)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN652575
291.50 $
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Immunogen This ESRRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-159 AA from the Central region of human ESRRA.
Clone RB22490
Isotype Ig
Specificity This ESRRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138~167 amino acids from the Center region of human ESRRA.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ESRRA
Background ESRRA is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes.
Synonyms: Steroid hormone receptor ERR1, Estrogen-related receptor, alpha, ERR-alpha, Estrogen receptor-like 1, Nuclear receptor subfamily 3 group B member 1, NR3B1, ESRL1, ERR1, ESRRA
Molecular Weight 45510 Da
Gene ID 2101
UniProt P11474
Research Area Transcription Factors, Signaling, Neurology
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Estrogen-Related Receptor alpha (ESRRA) (AA 131-159), (Center) antibody Western blot analysis of ESRRA Antibody (Center) (ABIN652575) in A375 cell line lysates (35 µg/lane). ESRRA (arrow) was detected using the purified polyclonal antibody.
anti-Estrogen-Related Receptor alpha (ESRRA) (AA 131-159), (Center) antibody (2) Formalin-fixed and paraffin-embedded human kidney carcinoma reacted with ESRRA Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Estrogen-Related Receptor alpha (ESRRA) (AA 131-159), (Center) antibody (3) Flow cytometric analysis of 293 cells using ESRRA Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Wiley, Kraus, Zuo et al.: "SV40 early-to-late switch involves titration of cellular transcriptional repressors." in: Genes & development, Vol. 7, Issue 11, pp. 2206-19, 1993 (PubMed).

Yang, Shigeta, Shi et al.: "Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter." in: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5795-804, 1996 (PubMed).

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