Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody

Details for Product No. ABIN652752
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Antigen
Synonyms SCNN1A, ENaCalpha, BESC2, ENaCa, SCNEA, SCNN1, alphaxENaC, besc2, enaca, scnn1, ENaC, Scnn1, mENaC, ENAC
Epitope
AA 365-391, Center
(20), (18), (7), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(39), (37), (18), (12), (12), (12)
Host
Rabbit
(59), (1), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(45), (28), (18), (12), (10), (6), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN652752
291.50 $
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Immunogen This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 AA from the Central region of human SCNN1A.
Clone RB21957
Isotype Ig
Specificity This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371~400 amino acids from the Center region of human SCNN1A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SCNN1A
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.
Synonyms: Alpha-NaCH, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, ENaCA, Amiloride-sensitive sodium channel subunit alpha, SCNN1A, SCNN1
Pathways: Aldosterone-regulated sodium reabsorption
Molecular Weight 28,328 Da Isoform 3 Da
Gene ID 6337
UniProt P37088
Research Area Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody Confocal immunofluorescent analysis of SCNN1A Antibody (Center) (ABIN652752) with Hela cell followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody (2) Western blot analysis of SCNN1A Antibody (Center) (ABIN652752) in WiDr cell line lysates (35 µg/lane). SCNN1A (arrow) was detected using the purified polyclonal antibody.
anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody (3) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SCNN1A Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Azad, Rauh, Vermeulen et al.: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).

Validation Images
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