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Details for Product No. ABIN652752

Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody

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Antigen
Synonyms BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1, ENaC, Scnn1, mENaC, SCNN1A, alphaxENaC, besc2, enaca, scnn1, ENAC
Epitope
»Alternatives AA 365-391, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
Pubmed 1 reference available
Catalog no. ABIN652752
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 AA from the Central region of human SCNN1A.
Clone RB21957
Isotype Ig
Specificity This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371~400 amino acids from the Center region of human SCNN1A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SCNN1A
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.
Synonyms: Alpha-NaCH, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, ENaCA, Amiloride-sensitive sodium channel subunit alpha, SCNN1A, SCNN1
Pathways: Aldosterone-regulated sodium reabsorption
Molecular Weight 28,328 Da Isoform 3 Da
Gene ID 6337
UniProt P37088
Research Area Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,IF : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Azad, Rauh, Vermeulen et al.: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).

Alternatives for antigen "Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A)", type "Antibodies"
Hosts (33), (1), (1)
Reactivities (29), (26), (23), (17), (17), (17)
Applications (18), (16), (10), (9), (6), (6), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2), (1), (1), (1), (1), (1)
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