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TCF3 (E2A) Fusion Partner (In Childhood Leukemia) (TFPT) (N-Term), (AA 60-88) antibody

Details for Product No. ABIN653252
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Antigen
Epitope
N-Term, AA 60-88
(8), (7), (4)
Reactivity
Human
(14), (2), (2)
Host
Rabbit
(14)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(14), (9), (8)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN653252
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Immunogen This TFPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-88 AA from the N-terminal region of human TFPT.
Clone RB24776
Isotype Ig
Specificity This TFPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67~97 amino acids from the N-terminal region of human TFPT.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TFPT
Background TFPT component of the chromatin-remodeling INO80 complex which, in addition to chromatin remodeling implicated in crucial functions such as DNA repair, checkpoint regulation, DNA replication, telomemere maintenance and chromosome segregation. This protein appears to promote apoptosis in a TP53/p53-independent manner.
Synonyms: INO80 complex subunit F, Protein FB1, TCF3 fusion partner, INO80F, TFPT
Molecular Weight 28278 DA
Gene ID 29844
UniProt P0C1Z6
Research Area Apoptosis/Necrosis, Neurology
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-TCF3 (E2A) Fusion Partner (In Childhood Leukemia) (TFPT) (N-Term), (AA 60-88) antibody Western blot analysis of TFPT Antibody (N-term) (ABIN653252) in MDA-MB435 cell line lysates (35 µg/lane). TFPT (arrow) was detected using the purified polyclonal antibody.
anti-TCF3 (E2A) Fusion Partner (In Childhood Leukemia) (TFPT) (N-Term), (AA 60-88) antibody (2) TFPT Antibody (N-term) (ABIN653252) flow cytometric analysis of MDA-MB435 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Franchini, Fontana, Minuzzo et al.: "Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced." in: Apoptosis : an international journal on programmed cell death, Vol. 11, Issue 12, pp. 2217-24, 2006 (PubMed).

Jiang, Ai, Xiao et al.: "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity." in: Cancer letters, Vol. 253, Issue 2, pp. 265-72, 2007 (PubMed).

Validation Images
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