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Inositol-Trisphosphate 3-Kinase C (ITPKC) (N-Term), (AA 89-117) antibody

Details for Product No. ABIN653274
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Antigen
Synonyms fi30c01, itpkc, wu:fi30c01, 9130023N17Rik, IP3-3KC, IP3KC
Epitope
N-Term, AA 89-117
(8), (8), (6), (2), (1), (1), (1), (1)
Reactivity
Human
(28)
Host
Rabbit
(21), (4), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(28), (20), (9), (7), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 400 µL
Options
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Catalog No. ABIN653274
291.50 $
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Immunogen This ITPKC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 AA from the N-terminal region of human ITPKC.
Clone RB23817
Isotype Ig
Specificity This ITPKC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96~125 amino acids from the N-terminal region of human ITPKC.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ITPKC
Background ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
Synonyms: Inositol 1,4,5-trisphosphate 3-kinase C, InsP 3-kinase C, IP3 3-kinase C, IP3K C, Inositol-trisphosphate 3-kinase C, IP3KC, ITPKC
Molecular Weight 75207 DA
Gene ID 80271
UniProt Q96DU7
Research Area Cancer, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (N-Term), (AA 89-117) antibody Western blot analysis of ITPKC Antibody (N-term) (ABIN653274) in HepG2 cell line lysates (35 µg/lane). ITPKC (arrow) was detected using the purified polyclonal antibody.
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (N-Term), (AA 89-117) antibody (2) Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ITPKC Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Inositol-Trisphosphate 3-Kinase C (ITPKC) (N-Term), (AA 89-117) antibody (3) ITPKC Antibody (N-term) (ABIN653274) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Nalaskowski, Windhorst, Stockebrand et al.: "Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains." in: Biological chemistry, Vol. 387, Issue 5, pp. 583-93, 2006 (PubMed).

Onouchi, Gunji, Burns et al.: "ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms." in: Nature genetics, Vol. 40, Issue 1, pp. 35-42, 2007 (PubMed).

Chi, Huang, Chen et al.: "ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children." in: Human molecular genetics, Vol. 19, Issue 6, pp. 1147-51, 2010 (PubMed).

Validation Images
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