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Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) (AA 236-263), (Center) antibody

Details for Product No. ABIN653837, Supplier: Log in to see
Antigen
  • cdc45l
  • cdc45l2
  • porc-pi-1
  • CDC45L
  • CDC45L2
  • PORC-PI-1
  • Cdc45l
Epitope
AA 236-263, Center
15
13
10
7
6
4
2
2
2
2
1
1
1
1
Reactivity
Human
75
25
25
1
1
1
1
Host
Rabbit
60
15
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
59
26
22
15
11
10
6
3
3
2
1
1
Supplier
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Immunogen This CDC45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 AA from the Central region of human CDC45L.
Clone RB23958
Isotype Ig
Specificity This CDC45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242~272 amino acids from the Central region of human CDC45L.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDC45L (CDC45 Antibody Abstract)
Background The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.
Synonyms: PORC-PI-1, CDC45-related protein, Cdc45,UNQ374/PRO710, CDC45L2, CDC45L
Molecular Weight 65569 DA
Gene ID 8318
UniProt O75419
Research Area Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Neurology, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) (AA 236-263), (Center) antibody (ABIN653837) Western blot analysis of CDC45L Antibody (Center) (ABIN653837) in 293 cell line lysat...
Immunohistochemistry (IHC) image for anti-Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) (AA 236-263), (Center) antibody (ABIN653837) CDC45L Antibody (Center) (ABIN653837) IHC analysis in formalin fixed and paraffin emb...
Flow Cytometry (FACS) image for anti-Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) (AA 236-263), (Center) antibody (ABIN653837) CDC45L Antibody (Center) (ABIN653837) flow cytometric analysis of 293 cells (right hi...
Background publications Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Ballabeni, Zamponi, Caprara et al.: "Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase." in: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3028-36, 2009 (PubMed).

Hoskins, Marcuello, Altes et al.: "Irinotecan pharmacogenetics: influence of pharmacodynamic genes." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 6, pp. 1788-96, 2008 (PubMed).