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Details for Product No. ABIN653837

Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) (AA 236-263), (Center) antibody

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Synonyms CDC45L, CDC45L2, PORC-PI-1, Cdc45l, cdc45l, cdc45l2, porc-pi-1
»Alternatives AA 236-263, Center
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN653837
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This CDC45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 AA from the Central region of human CDC45L.
Clone RB23958
Isotype Ig
Specificity This CDC45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242~272 amino acids from the Central region of human CDC45L.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDC45L
Background The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.
Synonyms: PORC-PI-1, CDC45-related protein, Cdc45,UNQ374/PRO710, CDC45L2, CDC45L
Molecular Weight 65569 DA
Gene ID 8318
UniProt O75419
Research Area Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Hoskins, Marcuello, Altes et al.: "Irinotecan pharmacogenetics: influence of pharmacodynamic genes." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 6, pp. 1788-96, 2008 (PubMed).

Ballabeni, Zamponi, Caprara et al.: "Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase." in: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3028-36, 2009 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Alternatives for antigen "Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45)", type "Antibodies"
Hosts (26), (11)
Reactivities (36), (16), (16), (11), (1), (1), (1), (1)
Applications (25), (11), (9), (4), (4), (3), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2), (1), (1), (1), (1)