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Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) (AA 10-36), (N-Term) antibody

Details for Product No. ABIN654117, Supplier: Login to see
Antigen
  • AKR1C3
  • PGFS
  • MGC134333
  • DD3
  • DDX
  • HA1753
  • HAKRB
  • HAKRe
  • HSD17B5
  • hluPGFS
  • Akr1c18
Alternatives
anti-Human Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) antibody for Western Blotting
Epitope
AA 10-36, N-Term
19
18
15
15
14
11
7
4
2
1
1
1
Reactivity
Human
105
7
7
1
Host
Rabbit
82
18
6
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
88
59
31
14
11
11
6
2
1
1
1
Supplier
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Immunogen This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 AA from the N-terminal region of human AKR1C3.
Clone RB22754
Isotype Ig
Specificity This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human AKR1C3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AKR1C3 (AKR1C3 Antibody Abstract)
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms: Aldo-keto reductase family 1 member C3,AKR1C3,DDH1, HSD17B5, KIAA0119, PGFS
Molecular Weight 36853 DA
Gene ID 8644
NCBI Accession NP_003730
UniProt P42330
Research Area Cell Structure
Pathways Retinoic Acid Receptor Signaling Pathway
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) (AA 10-36), (N-Term) antibody (ABIN654117) AKR1C3 Antibody (N-term) (ABIN654117) flow cytometric analysis of K562 cells (right h...
Product cited in: Guo, Wang, Liu et al.: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." in: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, 2014 (PubMed).

Background publications Wang, Chorley, Pittman et al.: "Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer." in: PLoS ONE, Vol. 5, Issue 8, pp. e11934, 2010 (PubMed).

Zakharov, Lin, Azzarello et al.: "Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma." in: International journal of clinical and experimental pathology, Vol. 3, Issue 6, pp. 608-17, 2010 (PubMed).

Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).