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Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) (AA 10-36), (N-Term) antibody

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Synonyms AKR1C3, PGFS, MGC134333, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, hluPGFS, Akr1c18
AA 10-36, N-Term
(19), (18), (15), (15), (14), (11), (7), (4), (2), (1), (1), (1)
(105), (7), (7), (1)
(82), (18), (6)
Clonality (Clone)
Polyclonal ()
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Western Blotting (WB)
(88), (59), (31), (14), (11), (11), (6), (2), (1), (1), (1)
Pubmed 6 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 AA from the N-terminal region of human AKR1C3.
Clone RB22754
Isotype Ig
Specificity This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human AKR1C3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AKR1C3 (AKR1C3 Antibody Abstract)
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms: Aldo-keto reductase family 1 member C3,AKR1C3,DDH1, HSD17B5, KIAA0119, PGFS
Molecular Weight 36853 DA
Gene ID 8644
NCBI Accession NP_003730
UniProt P42330
Research Area Cell Structure
Pathways Retinoic Acid Receptor Signaling Pathway
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) (AA 10-36), (N-Term) antibody (ABIN654117) AKR1C3 Antibody (N-term) (ABIN654117) flow cytometric analysis of K562 cells (right h...
Product cited in: Guo, Wang, Liu et al.: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." in: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, 2014 (PubMed).

Background publications Wang, Chorley, Pittman et al.: "Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer." in: PLoS ONE, Vol. 5, Issue 8, pp. e11934, 2010 (PubMed).

Zakharov, Lin, Azzarello et al.: "Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma." in: International journal of clinical and experimental pathology, Vol. 3, Issue 6, pp. 608-17, 2010 (PubMed).

Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Catalog No. ABIN654117
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