Kruppel-Like Factor 14 (KLF14) (C-Term), (AA 254-283) antibody

Details for Product No. ABIN654237
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Antigen
Epitope
C-Term, AA 254-283
(7), (6), (2)
Reactivity
Human, Mouse (Murine)
(10), (1), (1)
Host
Rabbit
(10)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(10), (7), (6)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN654237
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Immunogen This KLF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 AA from the C-terminal region of human KLF14.
Clone RB27698
Isotype Ig
Specificity This KLF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-291 amino acids from the C-terminal region of human KLF14.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KLF14
Background This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.
Synonyms: Krueppel-like factor 14,KLF14,BTEB5
Molecular Weight 33124 DA
Gene ID 136259
NCBI Accession NP_619638
UniProt Q8TD94
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Kruppel-Like Factor 14 (KLF14) (C-Term), (AA 254-283) antibody KLF14 Antibody (C-term) (ABIN654237) western blot analysis in mouse kidney tissue lysates (35 µg/lane). This demonstrates the EKI2 antibody detected the EKI2 protein (arrow).
Background publications Truty, Lomberk, Fernandez-Zapico et al.: "Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling." in: The Journal of biological chemistry, Vol. 284, Issue 10, pp. 6291-300, 2009 (PubMed).

Stacey, Sulem, Masson et al.: "New common variants affecting susceptibility to basal cell carcinoma." in: Nature genetics, Vol. 41, Issue 8, pp. 909-14, 2009 (PubMed).

Chasman, Paré, Mora et al.: "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis." in: PLoS genetics, Vol. 5, Issue 11, pp. e1000730, 2009 (PubMed).

Voight, Scott, Steinthorsdottir et al.: "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." in: Nature genetics, Vol. 42, Issue 7, pp. 579-89, 2010 (PubMed).

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