ALX Homeobox 4 (ALX4) (AA 249-275), (Center) antibody

Details for Product No. ABIN654344
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Antigen
Synonyms im:7142878, zgc:162606, alx4, FND2, lst
Epitope
AA 249-275, Center
(8), (8), (6), (3), (2), (1)
Reactivity
Human
(33), (13), (7), (5), (4), (1)
Host
Rabbit
(27), (11)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(37), (10), (10), (2), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN654344
291.50 $
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Immunogen This ALX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-275 AA from the Central region of human ALX4.
Clone RB28072
Isotype Ig
Specificity This ALX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-283 amino acids from the Central region of human ALX4.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ALX4
Background This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2), an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism, suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS), a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq].
Synonyms: Homeobox protein aristaless-like 4,ALX4,KIAA1788
Molecular Weight 44241 DA
Gene ID 60529
NCBI Accession NP_068745
UniProt Q9H161
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ALX Homeobox 4 (ALX4) (AA 249-275), (Center) antibody ALX4 Antibody (Center) (ABIN654344) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Drenos, Talmud, Casas et al.: "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk." in: Human molecular genetics, Vol. 18, Issue 12, pp. 2305-16, 2009 (PubMed).

Chang, Mohabir, Done et al.: "Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer." in: Journal of clinical pathology, Vol. 62, Issue 10, pp. 908-14, 2009 (PubMed).

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