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Complement Factor H antibody (CFH) (AA 751-780)

Details for Product anti-CFH Antibody No. ABIN654896, Supplier: Log in to see
Antigen
  • CFH
  • im:7147412
  • si:ch211-207o17.2
  • Mud-1
  • NOM
  • Sas-1
  • Sas1
  • AHUS1
  • AMBP1
  • ARMD4
  • ARMS1
  • CFHL3
  • FH
  • FHL1
  • HF
  • HF1
  • HF2
  • HUS
  • Fh
  • fH
Alternatives
anti-Human Complement Factor H antibody for Enzyme Immunoassay
Epitope
AA 751-780, Center
25
17
17
13
9
5
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
204
30
24
3
3
2
2
1
1
Host
Rabbit
92
71
31
27
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
This Complement Factor H antibody is un-conjugated
17
11
5
3
3
3
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
138
124
43
38
31
22
21
17
13
11
9
6
5
4
2
1
1
1
1
1
1
Supplier
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Immunogen This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 AA from the Central region of human CFH.
Clone RB18698
Isotype Ig
Specificity This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human CFH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CFH (CFH Antibody Abstract)
Background This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms: Complement factor H,CFH,HF, HF1, HF2
Molecular Weight 139096 DA
Gene ID 3075
NCBI Accession NP_000177
UniProt P08603
Research Area Cell Signaling, Protein Modifications, Cell Structure
Pathways Complement System
Application Notes WB = 1:1000, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.287 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Complement Factor H antibody (CFH) (AA 751-780) (ABIN654896) CFH Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).Th...
Immunohistochemistry (IHC) image for anti-Complement Factor H antibody (CFH) (AA 751-780) (ABIN654896) CFH antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin e...
Immunofluorescence (IF) image for anti-Complement Factor H antibody (CFH) (AA 751-780) (ABIN654896) Confocal immunofluorescent analysis of CFH Antibody (Center) with A549 cell followed...
Background publications Scambi, La Verde, De Franceschi et al.: "Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H." in: PLoS ONE, Vol. 5, Issue 8, pp. e12162, 2010 (PubMed).

Bunkenborg, Pilch, Podtelejnikov et al.: "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." in: Proteomics, Vol. 4, Issue 2, pp. 454-65, 2004 (PubMed).