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Details for Product No. ABIN654896

Complement Factor H (CFH) (AA 751-780), (Center) antibody

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Antigen
Synonyms HF1, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF2, HUS, NOM, Sas1, Mud-1, Sas-1, Fh, CFH, im:7147412, si:ch211-207o17.2
Epitope
»Alternatives AA 751-780, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN654896
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 AA from the Central region of human CFH.
Clone RB18698
Isotype Ig
Specificity This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human CFH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CFH
Background This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms: Complement factor H,CFH,HF, HF1, HF2
Molecular Weight 139096 DA
Gene ID 3075
UniProt NP_000177.2, P08603
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.287 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Bunkenborg, Pilch, Podtelejnikov et al.: "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." in: Proteomics, Vol. 4, Issue 2, pp. 454-65, 2004 (PubMed).

Scambi, La Verde, De Franceschi et al.: "Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H." in: PLoS ONE, Vol. 5, Issue 8, pp. e12162, 2010 (PubMed).

Alternatives for antigen "Complement Factor H (CFH)", type "Antibodies"
Hosts (44), (36), (20), (16), (1), (1)
Reactivities (112), (18), (17), (3), (2), (2), (1)
Applications (70), (64), (28), (20), (14), (10), (10), (10), (5), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Conjugates (6), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (6), (3), (2), (1), (1), (1), (1)
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