Complement Factor H (CFH) (AA 751-780), (Center) antibody

Details for Product No. ABIN654896
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Antigen
Synonyms CFH, im:7147412, si:ch211-207o17.2, Mud-1, NOM, Sas-1, Sas1, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, Fh, fH
Epitope
AA 751-780, Center
(12), (9), (6), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(129), (20), (18), (2), (2), (1), (1)
Host
Rabbit
(62), (35), (20), (15), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(80), (70), (31), (20), (17), (15), (13), (11), (11), (11), (9), (4), (3), (3), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN654896
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Immunogen This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 AA from the Central region of human CFH.
Clone RB18698
Isotype Ig
Specificity This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human CFH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CFH
Background This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms: Complement factor H,CFH,HF, HF1, HF2
Molecular Weight 139096 DA
Gene ID 3075
NCBI Accession NP_000177
UniProt P08603
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.287 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Complement Factor H (CFH) (AA 751-780), (Center) antibody Confocal immunofluorescent analysis of CFH Antibody (Center) with A549 cell followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
anti-Complement Factor H (CFH) (AA 751-780), (Center) antibody (2) CFH Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CFH antibody detected the CFH protein (arrow).
anti-Complement Factor H (CFH) (AA 751-780), (Center) antibody (3) CFH antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CFH antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Bunkenborg, Pilch, Podtelejnikov et al.: "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." in: Proteomics, Vol. 4, Issue 2, pp. 454-65, 2004 (PubMed).

Scambi, La Verde, De Franceschi et al.: "Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H." in: PLoS ONE, Vol. 5, Issue 8, pp. e12162, 2010 (PubMed).

Validation Images
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