Forkhead Box A2 (FOXA2) (AA 128-157), (Center) antibody

Details for Product No. ABIN655072
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Antigen
Synonyms
hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF3B, TCF3B, HNF-3B, ax, axl, fkd1, ik:tdsubc_2g8, tdsubc_2g8, wu:fe05g04, xx:tdsubc_2g8, FoxA2-A, FoxA2a, xFD-3, xbeta-1, HNF-3b, HNF3-beta, HNF3beta, Hnf-3 ... show more
hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF3B, TCF3B, HNF-3B, ax, axl, fkd1, ik:tdsubc_2g8, tdsubc_2g8, wu:fe05g04, xx:tdsubc_2g8, FoxA2-A, FoxA2a, xFD-3, xbeta-1, HNF-3b, HNF3-beta, HNF3beta, Hnf-3b, Hnf3b, Tcf-3b, Tcf3b, HNF-3BETA show less
Epitope
AA 128-157, Center
(15), (13), (12), (10), (8), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(103), (22), (19), (13), (12), (12), (3), (1), (1)
Host
Rabbit
(52), (45), (10)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(97), (61), (29), (25), (22), (15), (12), (10), (8), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN655072
291.50 $
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Immunogen This FOXA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 AA from the Central region of human FOXA2.
Clone RB19433
Isotype Ig
Specificity This FOXA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the Central region of human FOXA2.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FOXA2
Background This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
Synonyms: Hepatocyte nuclear factor 3-beta,FOXA2,HNF3B, TCF3B
Molecular Weight 48306 DA
Gene ID 3170
NCBI Accession NP_068556, NP_710141
UniProt Q9Y261
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Forkhead Box A2 (FOXA2) (AA 128-157), (Center) antibody FOXA2 Antibody (Center) (ABIN655072) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the FOXA2 antibody detected the FOXA2 protein (arrow).
Background publications Xing, Cohen, Boerwinkle: "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels." in: American journal of human genetics, Vol. 86, Issue 3, pp. 440-6, 2010 (PubMed).

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010 (PubMed).

Dayoub, Groitl, Dobner et al.: "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells." in: Biochemical and biophysical research communications, Vol. 395, Issue 4, pp. 465-70, 2010 (PubMed).

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