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Details for Product No. ABIN655175

Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) (C-Term), (AA 514-543) antibody

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Antigen
Synonyms CPSQ1, GAD, SCP, GAD67, GAD-67, GAD1, GLUTAMATE DECARBOXYLASE, GLUTAMATE DECARBOXYLASE 1, MKP11.30, MKP11_30, glutamate decarboxylase, cpsq1, gad1, gad1-A, gad67, GAD2, AO090005000539, AO090103000342
Epitope
»Alternatives C-Term, AA 514-543
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN655175
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This GAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-543 AA from the C-terminal region of human GAD1.
Clone RB19329
Isotype Ig
Specificity This GAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-551 amino acids from the C-terminal region of human GAD1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GAD1
Background This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Synonyms: GAD1,Glutamate decarboxylase 1,GAD, GAD67
Molecular Weight 66897 DA
Gene ID 2571
UniProt NP_000808, Q99259
Research Area Cell Structure, Metabolism
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Alternatives for antigen "Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1)", type "Antibodies"
Hosts (74), (16), (10), (5)
Reactivities (94), (52), (49), (7), (5), (5), (3), (1), (1), (1), (1)
Applications (80), (36), (31), (22), (10), (9), (7), (5), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (8), (7), (7), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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