7-Dehydrocholesterol Reductase (DHCR7) (C-Term), (AA 437-463) antibody

Details for Product No. ABIN655399
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Synonyms SLOS, AA409147, xdhcr7, 7-Dhcr, Xdhcr7, MGC64361, slos, 7-STEROL DELTA7 REDUCTASE, 7RED, DELTA5, DWARF 5, F11F12.21, F11F12_21, LE, LEPIDA, PA, PARVA, ST7R, STEROL DELTA7 REDUCTASE, DKFZp468C1911
C-Term, AA 437-463
(2), (2), (1), (1)
Mouse (Murine)
(17), (15), (13), (12), (12), (12)
(17), (1)
Clonality (Clone)
Polyclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(10), (9), (7), (6), (3), (3), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN655399
Quantity 400 µL
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Immunogen This DHCR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-463 AA from the C-terminal region of human DHCR7.
Clone RB17942
Isotype Ig
Specificity This DHCR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-471 amino acids from the C-terminal region of human DHCR7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DHCR7
Background This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
Synonyms: DHCR7,7-dehydrocholesterol reductase,D7SR
Molecular Weight 54489 DA
Gene ID 1717
UniProt NP_001157289.1, Q9UBM7, NP_001351.2
Research Area Cell Structure, Protein Modifications, Metabolism, Phospho-specific antibodies
Application Notes WB = 1:1000, IHC = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.31 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-7-Dehydrocholesterol Reductase (DHCR7) (C-Term), (AA 437-463) antibody DHCR7 Antibody (C-term) (ABIN655399) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Hosts (17), (1)
Reactivities (17), (15), (13), (12), (12), (12)
Applications (10), (9), (7), (6), (3), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (1), (1)
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