Killin, p53-Regulated DNA Replication Inhibitor (KLLN) (AA 136-163), (C-Term) antibody

Details for Product No. ABIN655558
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Synonyms CWS4, KILLIN
AA 136-163, C-Term
(17), (17), (1), (1)
(35), (2), (2)
Clonality (Clone)
Polyclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(25), (13), (10), (3), (3), (1)
Pubmed 4 references available
Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 AA from the C-terminal region of human KILLIN.
Clone RB29503
Isotype Ig
Specificity This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the C-terminal region of human KILLIN.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KILLIN (KLLN Antibody Abstract)
Background DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating TP53/p53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double-and single-stranded DNA.
Synonyms: Killin
Molecular Weight 19958 DA
Gene ID 100144748
NCBI Accession NP_001119521
UniProt B2CW77
Research Area Apoptosis/Necrosis, Cell Structure, Signaling, Transcription Factors
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Killin, p53-Regulated DNA Replication Inhibitor (KLLN) (AA 136-163), (C-Term) antibody (ABIN655558) KILLIN Antibody (C-term) (ABIN655558) western blot analysis in MDA-MB435 cell line ly...
Product cited in: Wang, Roma, Nolley et al.: "Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma." in: Endocrine-related cancer, Vol. 21, Issue 4, pp. 579-86, 2014 (PubMed).

Wang, Yu, He et al.: "Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation." in: Molecular cancer therapeutics, Vol. 13, Issue 2, pp. 517-27, 2014 (PubMed).

Wang, He, Yu et al.: "Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2263-72, 2013 (PubMed).

Background publications Cho, Liang: "Killin is a p53-regulated nuclear inhibitor of DNA synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 14, pp. 5396-401, 2008 (PubMed).

Catalog No. ABIN655558
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