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Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) (AA 194-222), (Center) antibody

Details for Product No. ABIN655589
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Antigen
Epitope
AA 194-222, Center
(12), (8), (7), (6), (5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(71), (30), (28), (1), (1), (1), (1)
Host
Rabbit
(54), (11), (5), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(57), (38), (16), (14), (11), (10), (8), (3), (2), (2)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN655589
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Immunogen This HEXIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 AA from the Central region of human HEXIM1.
Clone RB29909
Isotype Ig
Specificity This HEXIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human HEXIM1.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HEXIM1
Background Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Synonyms: Protein HEXIM1,HEXIM1,CLP1, EDG1, HIS1, MAQ1
Molecular Weight 40623 DA
Gene ID 10614
UniProt O94992, NP_006451.1
Research Area Cell Structure, Signaling, Protein Modifications, Phospho-specific antibodies, Transcription Factors, Translation Factors
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) (AA 194-222), (Center) antibody HEXIM1 antibody (Center) (ABIN655589) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Dow, Liu, Rice: "T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes." in: Journal of cellular physiology, Vol. 224, Issue 1, pp. 84-93, 2010 (PubMed).

Schönichen, Bigalke, Urbanke et al.: "A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1." in: Biochemistry, Vol. 49, Issue 14, pp. 3083-91, 2010 (PubMed).

Ogba, Doughman, Chaplin et al.: "HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland." in: Oncogene, Vol. 29, Issue 25, pp. 3639-49, 2010 (PubMed).

Validation Images
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