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Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (C-Term), (AA 1078-1105) antibody

Details for Product No. ABIN656023
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Antigen
Synonyms HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B, Zfx1b, Zfhx1b, Zfxh1b, mKIAA0569, 9130203F04Rik, D130016B08Rik, sip1, XSip1, zfhx1b, si:dkey-52o2.2, sip1a, wu:fc92g08, sip1b, ZEB2
Epitope
C-Term, AA 1078-1105
(18), (11), (7), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(56), (28), (27), (3), (3), (2), (2)
Host
Rabbit
(45), (7), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(54), (39), (16), (14), (10), (9), (7), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN656023
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This ZEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1078-1105 AA from the C-terminal region of human ZEB2.
Clone RB19137
Isotype Ig
Specificity This ZEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1085-1113 amino acids from the C-terminal region of human ZEB2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ZEB2
Background The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
Synonyms: ZEB2,Zinc finger E-box-binding homeobox 2,KIAA0569, SIP1, ZFHX1B, ZFX1B
Molecular Weight 136447 DA
Gene ID 9839
UniProt O60315, NP_055610.1, NP_001165124.1
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Neurology, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (C-Term), (AA 1078-1105) antibody ZEB2 Antibody (C-term) (ABIN656023) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Ohashi, Natsuizaka, Wong et al.: "Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors." in: Cancer research, Vol. 70, Issue 10, pp. 4174-84, 2010 (PubMed).

Li, Omura, Hong et al.: "Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels." in: Cancer research, Vol. 70, Issue 13, pp. 5226-37, 2010 (PubMed).

Kumar, Kotlyarevska, Dejkhmaron et al.: "Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31148-56, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN656023
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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