Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 171-198), (Center) antibody

Details for Product No. ABIN656176
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Antigen
Synonyms CREB2, TXREB, CREB-2, TAXREB67, Atf-4, C/ATF, atf-4, atf4, creb-2, creb2, taxreb67, txreb, wu:fj01c08, wu:fk30b04, zgc:85951, ATF4, ATF4C, sb:eu681, wu:fb08f07, zgc:171702
Epitope
AA 171-198, Center
(31), (18), (14), (9), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(129), (51), (50), (16), (14), (13), (1), (1)
Host
Rabbit
(107), (28), (11)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(94), (59), (52), (26), (24), (20), (5), (4), (2), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN656176
Quantity 400 µL
Price
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Immunogen This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-198 AA from the Central region of human ATF4.
Clone RB32222
Isotype Ig
Specificity This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human ATF4.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ATF4
Background This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
Synonyms: ATF4,Cyclic AMP-dependent transcription factor ATF-4,CREB2, TXREB
Molecular Weight 38590 DA
Gene ID 468
UniProt P18848, NP_001666.2
Research Area Translation Factors, Phospho-specific antibodies, Cell Structure, Protein Modifications, Transcription Factors, Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment ATF4 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 171-198), (Center) antibody ATF4 Antibody (Center) (ABIN656176) western blot analysis in MDA-MB435 cell line lysates (35 µg/lane). This demonstrates the ATF4 antibody detected the ATF4 protein (arrow).
Background publications Rzymski, Milani, Pike et al.: "Regulation of autophagy by ATF4 in response to severe hypoxia." in: Oncogene, Vol. 29, Issue 31, pp. 4424-35, 2010 (PubMed).

Wek, Staschke: "How do tumours adapt to nutrient stress?" in: The EMBO journal, Vol. 29, Issue 12, pp. 1946-7, 2010 (PubMed).

Liew, Bochenski, Kawamori et al.: "The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2876-88, 2010 (PubMed).

Frank, Ge, Xie et al.: "Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33324-37, 2010 (PubMed).

Dey, Baird, Zhou et al.: "Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33165-74, 2010 (PubMed).

Hosts (107), (28), (11)
Reactivities (129), (51), (50), (16), (14), (13), (1), (1)
Applications (94), (59), (52), (26), (24), (20), (5), (4), (2), (2), (1), (1)
Conjugates (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (31), (18), (14), (9), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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