Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 321-349), (Center) antibody

Details for Product No. ABIN656275
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Antigen
Synonyms GCK, BL44, RAB8IP
Epitope
AA 321-349, Center
(4), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(17), (6), (4), (2), (2), (1), (1)
Host
Rabbit
(18), (2)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Flow Cytometry (FACS)
(18), (6), (3), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN656275
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This MAP4K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-349 AA from the Central region of human MAP4K2.
Clone RB32275
Isotype Ig
Specificity This MAP4K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-349 amino acids from the Central region of human MAP4K2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAP4K2
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Synonyms: MAP4K2,Mitogen-activated protein kinase kinase kinase kinase 2,GCK, RAB8IP
Molecular Weight 91556 DA
Gene ID 5871
UniProt Q12851, NP_004570.2
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MAP4K2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 321-349), (Center) antibody MAP4K2 Antibody (Center) (ABIN656275) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the MAP4K2 antibody detected the MAP4K2 protein (arrow).
Background publications Chadee, Yuasa, Kyriakis: "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2." in: Molecular and cellular biology, Vol. 22, Issue 3, pp. 737-49, 2002 (PubMed).

Fidalgo, Fraile, Pires et al.: "CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation." in: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1274-84, 2010 (PubMed).

Hosts (18), (2)
Reactivities (17), (6), (4), (2), (2), (1), (1)
Applications (18), (6), (3), (2), (2), (2), (1), (1), (1)
Epitopes (4), (2), (2), (2), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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