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Details for Product No. ABIN656275

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 321-349), (Center) antibody

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Antigen
Synonyms GCK, BL44, RAB8IP
Epitope
»Alternatives AA 321-349, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN656275
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This MAP4K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-349 AA from the Central region of human MAP4K2.
Clone RB32275
Isotype Ig
Specificity This MAP4K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-349 amino acids from the Central region of human MAP4K2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAP4K2
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Synonyms: MAP4K2,Mitogen-activated protein kinase kinase kinase kinase 2,GCK, RAB8IP
Molecular Weight 91556 DA
Gene ID 5871
UniProt Q12851, NP_004570.2
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment MAP4K2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Chadee, Yuasa, Kyriakis: "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2." in: Molecular and cellular biology, Vol. 22, Issue 3, pp. 737-49, 2002 (PubMed).

Fidalgo, Fraile, Pires et al.: "CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation." in: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1274-84, 2010 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)", type "Antibodies"
Hosts (17), (1)
Reactivities (14), (7), (4), (2), (2), (1), (1)
Applications (16), (8), (2), (2), (2), (1), (1), (1), (1)
Epitopes (4), (2), (2), (1), (1), (1), (1), (1)
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