Dystrobrevin alpha (DTNA) (C-Term), (AA 692-721) antibody

Details for Product No. ABIN656504
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Antigen
Synonyms adtn, atnb, MGC146484, 2210407P21Rik, A0, Dtn, a-DB-1, adbn, D18S892E, DRP3, DTN, DTN-A, LVNC1, Dtna-ps1, RGD1561985
Epitope
C-Term, AA 692-721
(11), (8), (2), (1), (1)
Reactivity
Mouse (Murine)
(41), (35), (26), (24), (24), (24), (1)
Host
Rabbit
(39), (10)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(31), (20), (11), (9), (8), (8), (7), (6), (3)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN656504
291.50 $
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Immunogen This DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 AA from the C-terminal region of human DTNA.
Clone RB31275
Isotype Ig
Specificity This DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 691-721 amino acids from the C-terminal region of human DTNA.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DTNA
Background The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Synonyms: Dystrobrevin alpha,DTNA,DRP3
Molecular Weight 83901 Da
Gene ID 1837
UniProt Q9Y4J8
Research Area Phospho-specific antibodies, Cell Structure, Protein Modifications, Neurology
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.44 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Dystrobrevin alpha (DTNA) (C-Term), (AA 692-721) antibody DTNA Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DTNA antibody detected the DTNA protein (arrow).
anti-Dystrobrevin alpha (DTNA) (C-Term), (AA 692-721) antibody (2) DTNA Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DTNA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Dystrobrevin alpha (DTNA) (C-Term), (AA 692-721) antibody (3) Confocal immunofluorescent analysis of DTNA Antibody (C-term) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Background publications Lim, Hao, Shaw et al.: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, 2006 (PubMed).

Böhm, Constantinou, Tan et al.: "Profound human/mouse differences in alpha-dystrobrevin isoforms: a novel syntrophin-binding site and promoter missing in mouse and rat." in: BMC biology, Vol. 7, pp. 85, 2009 (PubMed).

Validation Images
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