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EIF3CL antibody (Eukaryotic Translation Initiation Factor 3, Subunit C-Like) (AA 127-155)

Details for Product anti-EIF3CL Antibody No. ABIN656540, Supplier: Log in to see
  • eukaryotic translation initiation factor 3, subunit C-like
  • EIF3CL
AA 127-155, N-Term
Clonality (Clone)
Polyclonal ()
This EIF3CL antibody is un-conjugated
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Immunogen This EIF3CL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 AA from the N-terminal region of human EIF3CL.
Clone RB32067
Isotype Ig
Specificity This EIF3CL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the N-terminal region of human EIF3CL.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name EIF3CL
Background Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Synonyms: Eukaryotic translation initiation factor 3 subunit C,EIF3C,EIF3S8
Molecular Weight 105344 DA
Gene ID 8663
NCBI Accession NP_001032897, NP_003743
UniProt Q99613
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.48 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment EIF3CL Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-EIF3CL antibody (Eukaryotic Translation Initiation Factor 3, Subunit C-Like) (AA 127-155) (ABIN656540) EIF3CL Antibody (N-term) (ABIN656540) immunohistochemistry analysis in formalin fixed...
Background publications Imielinski, Baldassano, Griffiths, Russell, Annese, Dubinsky, Kugathasan, Bradfield, Walters, Sleiman, Kim, Muise, Wang, Glessner, Saeed, Zhang, Frackelton, Hou, Flory, Otieno, Chiavacci, Grundmeier, Castro, Latiano, Dallapiccola, Stempak, Abrams, Taylor,: "Common variants at five new loci associated with early-onset inflammatory bowel disease." in: Nature genetics, Vol. 41, Issue 12, pp. 1335-40, 2009 (PubMed).

Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, 2008 (PubMed).

Masutani, Sonenberg, Yokoyama, Imataka: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, 2007 (PubMed).