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Details for Product No. ABIN656568

Interferon Regulatory Factor 4 (IRF4) (AA 164-191), (Center) antibody

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Antigen
Synonyms LSIRF, MUM1, NF-EM5, Spip, IRF-4, AI385587, si:ch73-170d1.2, IRF4, irf4
Epitope
»Alternatives AA 164-191, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN656568
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This IRF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-191 AA from the Central region of human IRF4.
Clone RB17417
Isotype Ig
Specificity This IRF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the Central region of human IRF4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IRF4
Background The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6,14)(p25,q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
Synonyms: Interferon regulatory factor 4,IRF4,MUM1
Molecular Weight 51772 DA
Gene ID 3662
UniProt Q15306, NP_001182215.1, NP_002451.2
Research Area Translation Factors, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment IRF4 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Ucisik-Akkaya, Davis, Do et al.: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).

Newton-Bishop, Chang, Iles et al.: "Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 8, pp. 2043-54, 2010 (PubMed).

Staudt, Bothur, Klein et al.: "Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells." in: Immunity, Vol. 33, Issue 2, pp. 192-202, 2010 (PubMed).

Alternatives for antigen "Interferon Regulatory Factor 4 (IRF4)", type "Antibodies"
Hosts (65), (24), (3), (1), (1)
Reactivities (92), (36), (24), (15), (14), (2), (2), (2), (1)
Applications (69), (35), (35), (10), (10), (7), (4), (3), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (6), (6), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1)
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