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Iron-Responsive Element Binding Protein 2 (IREB2) (AA 201-230), (Center) antibody

Details for Product No. ABIN656586
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Antigen
Synonyms IREB2, im:7153062, DKFZp468N047, D9Ertd85e, Irp2, ACO3, IRP2, IRP2AD, IREBP2
Epitope
AA 201-230, Center
(10), (10), (6), (5), (5), (3), (2), (1), (1)
Reactivity
Human
(22), (18), (5), (1), (1), (1)
Host
Rabbit
(31), (6), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(41), (15), (7), (6), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN656586
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Immunogen This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 AA from the Central region of human IREB2.
Clone RB30212
Isotype Ig
Specificity This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IREB2
Background IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Synonyms: Iron-responsive element-binding protein 2,IREB2,
Molecular Weight 105045 DA
Gene ID 3658
UniProt NP_004127.1, P48200
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment IREB2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Iron-Responsive Element Binding Protein 2 (IREB2) (AA 201-230), (Center) antibody IREB2 Antibody (Center) (ABIN656586) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Salahudeen, Thompson, Ruiz et al.: "An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis." in: Science (New York, N.Y.), Vol. 326, Issue 5953, pp. 722-6, 2009 (PubMed).

DeMeo, Mariani, Bhattacharya et al.: "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." in: American journal of human genetics, Vol. 85, Issue 4, pp. 493-502, 2009 (PubMed).

Cho, Boutaoui, Klanderman et al.: "Variants in FAM13A are associated with chronic obstructive pulmonary disease." in: Nature genetics, Vol. 42, Issue 3, pp. 200-2, 2010 (PubMed).

Hansen, Xiao, Rice et al.: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, 2010 (PubMed).

Ucisik-Akkaya, Davis, Do et al.: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).

Validation Images
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