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Iron-Responsive Element Binding Protein 2 (IREB2) (AA 201-230), (Center) antibody

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Synonyms IREB2, im:7153062, DKFZp468N047, D9Ertd85e, Irp2, ACO3, IRP2, IRP2AD, IREBP2
AA 201-230, Center
(22), (14), (10), (6), (4), (3), (3), (1), (1), (1), (1), (1), (1)
(59), (11), (7), (2), (2), (1), (1), (1), (1), (1)
(37), (18), (10)
Clonality (Clone)
Polyclonal ()
(3), (3), (3), (3), (2), (2)
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(60), (39), (22), (14), (10), (4), (4), (3), (2)
Pubmed 5 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 AA from the Central region of human IREB2.
Clone RB30212
Isotype Ig
Specificity This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IREB2 (IREB2 Antibody Abstract)
Background IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Synonyms: Iron-responsive element-binding protein 2,IREB2,
Molecular Weight 105045 DA
Gene ID 3658
NCBI Accession NP_004127
UniProt P48200
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment IREB2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Iron-Responsive Element Binding Protein 2 (IREB2) (AA 201-230), (Center) antibody (ABIN656586) IREB2 Antibody (Center) (ABIN656586) immunohistochemistry analysis in formalin fixed ...
Background publications Ucisik-Akkaya, Davis, Do et al.: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).

Hansen, Xiao, Rice et al.: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, 2010 (PubMed).

Cho, Boutaoui, Klanderman et al.: "Variants in FAM13A are associated with chronic obstructive pulmonary disease." in: Nature genetics, Vol. 42, Issue 3, pp. 200-2, 2010 (PubMed).

DeMeo, Mariani, Bhattacharya et al.: "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." in: American journal of human genetics, Vol. 85, Issue 4, pp. 493-502, 2009 (PubMed).

Salahudeen, Thompson, Ruiz et al.: "An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis." in: Science (New York, N.Y.), Vol. 326, Issue 5953, pp. 722-6, 2009 (PubMed).

Catalog No. ABIN656586
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