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SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) (AA 879-908), (Center) antibody

Details for Product No. ABIN656710, Supplier: Login to see
Antigen
  • shank2
  • MGC122482
  • SHANK2
  • AUTS17
  • CORTBP1
  • CTTNBP1
  • ProSAP1
  • SHANK
  • SPANK-3
  • CortBP1
  • Spank-3
  • auts17
  • cortbp1
  • cttnbp1
  • prosap1
  • spank-3
  • mKIAA1022
Epitope
AA 879-908, Center
75
19
19
17
16
11
4
3
3
2
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
94
79
73
4
Host
Rabbit
84
49
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
6
6
6
5
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
119
86
77
38
23
11
7
6
4
1
1
Supplier
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Immunogen This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 AA from the Central region of human SHANK2.
Clone RB31120
Isotype Ig
Specificity This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 886-916 amino acids from the Central region of human SHANK2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SHANK2 (SHANK2 Antibody Abstract)
Background This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].
Synonyms: SH3 and multiple ankyrin repeat domains protein 2,SHANK2,CORTBP1, KIAA1022, PROSAP1
Molecular Weight 158822 DA
Gene ID 22941
NCBI Accession NP_036441
UniProt Q9UPX8
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SHANK2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) (AA 879-908), (Center) antibody (ABIN656710) SHANK2 Antibody (Center) (ABIN656710) western blot analysis in mouse bladder tissue l...
Background publications Pinto, Pagnamenta, Klei et al.: "Functional impact of global rare copy number variation in autism spectrum disorders." in: Nature, Vol. 466, Issue 7304, pp. 368-72, 2010 (PubMed).

Berkel, Marshall, Weiss et al.: "Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation." in: Nature genetics, Vol. 42, Issue 6, pp. 489-91, 2010 (PubMed).

Lee, Lee, Kim et al.: "BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8104-13, 2010 (PubMed).