SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) (AA 879-908), (Center) antibody

Details for Product No. ABIN656710
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Antigen
Synonyms shank2, MGC122482, SHANK2, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, CortBP1, Spank-3, auts17, cortbp1, cttnbp1, prosap1, spank-3, mKIAA1022
Epitope
AA 879-908, Center
(40), (10), (8), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(56), (41), (24), (12), (12), (4)
Host
Rabbit
(49), (38), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(78), (50), (40), (38), (18), (10), (7), (4), (4), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN656710
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Immunogen This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 AA from the Central region of human SHANK2.
Clone RB31120
Isotype Ig
Specificity This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 886-916 amino acids from the Central region of human SHANK2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SHANK2
Background This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].
Synonyms: SH3 and multiple ankyrin repeat domains protein 2,SHANK2,CORTBP1, KIAA1022, PROSAP1
Molecular Weight 158822 DA
Gene ID 22941
NCBI Accession NP_036441
UniProt Q9UPX8
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SHANK2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) (AA 879-908), (Center) antibody SHANK2 Antibody (Center) (ABIN656710) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow).
Background publications Lee, Lee, Kim et al.: "BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8104-13, 2010 (PubMed).

Berkel, Marshall, Weiss et al.: "Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation." in: Nature genetics, Vol. 42, Issue 6, pp. 489-91, 2010 (PubMed).

Pinto, Pagnamenta, Klei et al.: "Functional impact of global rare copy number variation in autism spectrum disorders." in: Nature, Vol. 466, Issue 7304, pp. 368-72, 2010 (PubMed).

Validation Images
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