Chromosome 10 Open Reading Frame 2 (C1ORF2) (C-Term), (AA 656-684) antibody

Details for Product No. ABIN656726
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Antigen
Epitope
C-Term, AA 656-684
(7), (6), (4), (2)
Reactivity
Human
(14), (4), (4), (2), (1), (1), (1)
Host
Rabbit
(14)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(14), (7), (6), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN656726
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Immunogen This C10orf2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-684 AA from the C-terminal region of human C10orf2.
Clone RB32016
Isotype Ig
Specificity This C10orf2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-684 amino acids from the C-terminal region of human C10orf2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name C10orf2
Background This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: Twinkle protein, mitochondrial,PEO1,C10orf2
Molecular Weight 77154 DA
Gene ID 56652
NCBI Accession NP_001157284, NP_068602
UniProt Q96RR1
Research Area Cell Signaling, Chromatin, Signaling, Metabolism, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment C10orf2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Chromosome 10 Open Reading Frame 2 (C1ORF2) (C-Term), (AA 656-684) antibody C10orf2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow).
anti-Chromosome 10 Open Reading Frame 2 (C1ORF2) (C-Term), (AA 656-684) antibody (2) C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Longley, Humble, Sharief et al.: "Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29690-702, 2010 (PubMed).

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