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Details for Product No. ABIN657000

WD Repeat Domain 12 (WDR12) (AA 210-239), (Center) antibody

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Antigen
Synonyms YTM1, Ytm1, Ytm1p, 4933402C23Rik, fb24f09, zgc:55609, wu:fb24f09, WDR12
Epitope
»Alternatives AA 210-239, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN657000
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 AA from the Central region of human WDR12.
Clone RB33036
Isotype Ig
Specificity This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human WDR12.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WDR12
Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
Synonyms: Ribosome biogenesis protein WDR12,WDR12,
Molecular Weight 47708 DA
Gene ID 55759
UniProt Q9GZL7, NP_060726.3
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment WDR12 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Hölzel, Rohrmoser, Schlee et al.: "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation." in: The Journal of cell biology, Vol. 170, Issue 3, pp. 367-78, 2005 (PubMed).

Grimm, Hölzel, Rohrmoser et al.: "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex." in: Nucleic acids research, Vol. 34, Issue 10, pp. 3030-43, 2006 (PubMed).

, Kathiresan, Voight et al.: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants." in: Nature genetics, Vol. 41, Issue 3, pp. 334-41, 2009 (PubMed).

Alternatives for antigen "WD Repeat Domain 12 (WDR12)", type "Antibodies"
Hosts (11)
Reactivities (9), (5), (1), (1), (1)
Applications (11), (2), (2), (1), (1)
Epitopes (2), (2), (2), (2), (1), (1)
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