WD Repeat Domain 12 (WDR12) (AA 210-239), (Center) antibody

Details for Product No. ABIN657000
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Antigen
Epitope
AA 210-239, Center
(13), (8), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(21), (4), (2), (2), (1)
Host
Rabbit
(22)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(22), (13), (6), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657000
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Immunogen This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 AA from the Central region of human WDR12.
Clone RB33036
Isotype Ig
Specificity This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human WDR12.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WDR12
Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
Synonyms: Ribosome biogenesis protein WDR12,WDR12,
Molecular Weight 47708 DA
Gene ID 55759
NCBI Accession NP_060726
UniProt Q9GZL7
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment WDR12 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-WD Repeat Domain 12 (WDR12) (AA 210-239), (Center) antibody WDR12 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the WDR12 antibody detected the WDR12 protein (arrow).
anti-WD Repeat Domain 12 (WDR12) (AA 210-239), (Center) antibody (2) WDR12 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of WDR12 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Hölzel, Rohrmoser, Schlee et al.: "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation." in: The Journal of cell biology, Vol. 170, Issue 3, pp. 367-78, 2005 (PubMed).

Grimm, Hölzel, Rohrmoser et al.: "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex." in: Nucleic acids research, Vol. 34, Issue 10, pp. 3030-43, 2006 (PubMed).

, Kathiresan, Voight et al.: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants." in: Nature genetics, Vol. 41, Issue 3, pp. 334-41, 2009 (PubMed).

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