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PHD Finger Protein 17 (PHF17) (N-Term), (AA 22-51) antibody

Details for Product No. ABIN657355
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Antigen
Synonyms fi11a04, jade1, wu:fi11a04, zgc:55323, JADE1, AU041499, D530048A03Rik, Jade1, mKIAA1807
Epitope
N-Term, AA 22-51
(9), (7), (4), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(13), (12), (4), (3), (3), (2), (2), (1), (1)
Host
Rabbit
(19), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(20), (8), (6), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN657355
291.50 $
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Immunogen This PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 AA from the N-terminal region of human PHF17.
Clone RB15092
Isotype Ig
Specificity This PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-51 amino acids from the N-terminal region of human PHF17.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PHF17
Background Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.
Synonyms: Protein Jade-1,PHF17,JADE1, KIAA1807
Molecular Weight 95533 DA
Gene ID 79960
UniProt NP_079176.2, Q6IE81, NP_955352.1
Research Area Apoptosis/Necrosis, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment PHF17 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-PHD Finger Protein 17 (PHF17) (N-Term), (AA 22-51) antibody PHF17 Antibody (N-term) (ABIN657355) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the PHF17 antibody detected the PHF17 protein (arrow).
Background publications Doyon, Cayrou, Ullah et al.: "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation." in: Molecular cell, Vol. 21, Issue 1, pp. 51-64, 2006 (PubMed).

Lim, Hao, Shaw et al.: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Foy, Song, Chitalia et al.: "Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex." in: The Journal of biological chemistry, Vol. 283, Issue 43, pp. 28817-26, 2008 (PubMed).

Chitalia, Foy, Bachschmid et al.: "Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL." in: Nature cell biology, Vol. 10, Issue 10, pp. 1208-16, 2008 (PubMed).

Validation Images
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