Tubulin Folding Cofactor C (TBCC) (N-Term), (AA 20-49) antibody

Details for Product No. ABIN657398
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Antigen
Epitope
N-Term, AA 20-49
(7), (6), (3), (2), (1)
Reactivity
Mouse (Murine)
(23), (11), (4), (1)
Host
Rabbit
(18), (11)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(26), (12), (10), (5), (3), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657398
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Immunogen This TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 AA from the N-terminal region of human TBCC.
Clone RB33319
Isotype Ig
Specificity This TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human TBCC.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TBCC
Background Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex, interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Synonyms: Tubulin-specific chaperone C,TBCC,
Molecular Weight 39248 DA
Gene ID 6903
NCBI Accession NP_003183
UniProt Q15814
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TBCC Antibody (N-term ) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Tubulin Folding Cofactor C (TBCC) (N-Term), (AA 20-49) antibody TBCC Antibody (N-term ) (ABIN657398) western blot analysis in mouse spleen tissue lysates (35 µg/lane). This demonstrates the TBCC antibody detected the TBCC protein (arrow).
Background publications Bartolini, Bhamidipati, Thomas et al.: "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 14629-34, 2002 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Hage-Sleiman, Herveau, Matera et al.: "Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells." in: BMC cancer, Vol. 10, pp. 135, 2010 (PubMed).

Validation Images
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