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Details for Product No. ABIN657619

Hemoglobin, gamma A (HBG1) (AA 56-85), (Center) antibody

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Antigen
Synonyms HBGA, HBGR, HSGGL1, Hbe1, Hbb-y, HBG1, HBG2
Epitope
»Alternatives AA 56-85, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN657619
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 AA from the Central region of human HBG1.
Clone RB33610
Isotype Ig
Specificity This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-85 amino acids from the Central region of human HBG1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HBG1
Background The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Synonyms: Hemoglobin subunit gamma-1,HBG1,
Molecular Weight 16140 DA
Gene ID 3047
UniProt NP_000550.2, P69891
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment HBG1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Zhou, Liu, Sun et al.: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." in: Nature genetics, Vol. 42, Issue 9, pp. 742-4, 2010 (PubMed).

Alternatives for antigen "Hemoglobin, gamma A (HBG1)", type "Antibodies"
Hosts (4), (2)
Reactivities (6)
Applications (4), (3)
Epitopes (3), (1), (1), (1), (1)
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