Hemoglobin, gamma A (HBG1) (AA 56-85), (Center) antibody

Details for Product No. ABIN657619
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Antigen
Synonyms Hbe1, Hbb-y, HBG1, HBGA, HBGR, HSGGL1, HBG2
Epitope
AA 56-85, Center
(6), (2), (1), (1), (1)
Reactivity
Human
(16)
Host
Rabbit
(12), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(13), (8)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN657619
291.50 $
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Immunogen This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 AA from the Central region of human HBG1.
Clone RB33610
Isotype Ig
Specificity This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-85 amino acids from the Central region of human HBG1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HBG1
Background The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Synonyms: Hemoglobin subunit gamma-1,HBG1,
Molecular Weight 16140 DA
Gene ID 3047
NCBI Accession NP_000550
UniProt P69891
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HBG1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Hemoglobin, gamma A (HBG1) (AA 56-85), (Center) antibody HBG1 Antibody (Center) (ABIN657619) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the HBG1 antibody detected the HBG1 protein (arrow).
Background publications Zhou, Liu, Sun et al.: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." in: Nature genetics, Vol. 42, Issue 9, pp. 742-4, 2010 (PubMed).

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