Napsin A Aspartic Peptidase (NAPSA) (C-Term), (AA 368-397) antibody

Details for Product No. ABIN657694
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Antigen
Epitope
C-Term, AA 368-397
(10), (8), (7), (4), (2), (1), (1), (1), (1)
Reactivity
Human
(57), (18), (18), (12), (12)
Host
Rabbit
(37), (17), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(38), (19), (15), (12), (10), (4), (2), (2), (2)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657694
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Immunogen This NAPSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-397 AA from the C-terminal region of human NAPSA.
Clone RB33879
Isotype Ig
Specificity This NAPSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-397 amino acids from the C-terminal region of human NAPSA.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NAPSA
Background The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq].
Synonyms: Napsin-A,NAPSA,NAP1, NAPA
Molecular Weight 45387 DA
Gene ID 9476
NCBI Accession NP_004842
UniProt O96009
Research Area Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NAPSA Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Napsin A Aspartic Peptidase (NAPSA) (C-Term), (AA 368-397) antibody NAPSA Antibody (C-term) (ABIN657694) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the NAPSA antibody detected the NAPSA protein (arrow).
Background publications Brasch, Ochs, Kahne et al.: "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung." in: The Journal of biological chemistry, Vol. 278, Issue 49, pp. 49006-14, 2003 (PubMed).

Innocenti, Zucconi, Disanza et al.: "Abi1 is essential for the formation and activation of a WAVE2 signalling complex." in: Nature cell biology, Vol. 6, Issue 4, pp. 319-27, 2004 (PubMed).

Bishop, Sharma, Illei: "Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma." in: Human pathology, Vol. 41, Issue 1, pp. 20-5, 2009 (PubMed).

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