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Ran GTPase Activating Protein 1 (RANGAP1) (AA 20-49), (N-Term) antibody

Details for Product No. ABIN657698, Supplier: Log in to see
Antigen
  • RanGAP1
  • fug1
  • rangap1b
  • rna1p
  • Fug1
  • RANGAP
  • SD
  • C79654
  • mKIAA1835
  • rangap1
  • rangap1a
  • ATRANGAP1
  • RAN GTPASE-ACTIVATING PROTEIN 1
  • RAN GTPase activating protein 1
Epitope
AA 20-49, N-Term
38
15
3
2
2
2
1
1
1
1
1
Reactivity
Human
75
34
27
7
4
4
1
1
1
Host
Rabbit
57
16
7
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
63
32
31
23
17
11
2
2
2
2
Supplier
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Immunogen This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 AA from the N-terminal region of human RANGAP1.
Clone RB33892
Isotype Ig
Specificity This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human RANGAP1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RANGAP1 (RANGAP1 Antibody Abstract)
Background RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Synonyms: Ran GTPase-activating protein 1,RANGAP1,KIAA1835, SD
Molecular Weight 63542 DA
Gene ID 5905
NCBI Accession NP_002874
UniProt P46060
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Cell Structure, Protein Modifications, Chromatin
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment RANGAP1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ran GTPase Activating Protein 1 (RANGAP1) (AA 20-49), (N-Term) antibody (ABIN657698) Western blot analysis of RANGAP1 (arrow) using rabbit polyclonal RANGAP1 Antibody (N-...
Background publications Zhang, Sarge: "Mel-18 interacts with RanGAP1 and inhibits its sumoylation." in: Biochemical and biophysical research communications, Vol. 375, Issue 2, pp. 252-5, 2008 (PubMed).

Zuccolo, Alves, Galy et al.: "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions." in: The EMBO journal, Vol. 26, Issue 7, pp. 1853-64, 2007 (PubMed).