Ran GTPase Activating Protein 1 (RANGAP1) (N-Term), (AA 20-49) antibody

Details for Product No. ABIN657698
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Antigen
Epitope
N-Term, AA 20-49
(18), (7), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(54), (25), (21), (14), (13), (11), (5)
Host
Rabbit
(42), (7), (7), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(44), (20), (18), (17), (16), (9), (5), (4), (3), (3), (2), (2)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN657698
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Immunogen This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 AA from the N-terminal region of human RANGAP1.
Clone RB33892
Isotype Ig
Specificity This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human RANGAP1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RANGAP1
Background RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Synonyms: Ran GTPase-activating protein 1,RANGAP1,KIAA1835, SD
Molecular Weight 63542 DA
Gene ID 5905
NCBI Accession NP_002874
UniProt P46060
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Cell Structure, Protein Modifications, Chromatin
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment RANGAP1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Ran GTPase Activating Protein 1 (RANGAP1) (N-Term), (AA 20-49) antibody Western blot analysis of RANGAP1 (arrow) using rabbit polyclonal RANGAP1 Antibody (N-term) (ABIN657698). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RANGAP1 gene.
Background publications Zuccolo, Alves, Galy et al.: "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions." in: The EMBO journal, Vol. 26, Issue 7, pp. 1853-64, 2007 (PubMed).

Zhang, Sarge: "Mel-18 interacts with RanGAP1 and inhibits its sumoylation." in: Biochemical and biophysical research communications, Vol. 375, Issue 2, pp. 252-5, 2008 (PubMed).

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