Centromere Protein A (CENPA) (AA 82-110), (Center) antibody

Details for Product No. ABIN657764
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Antigen
Epitope
AA 82-110, Center
(20), (14), (7), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(96), (15), (13), (13), (12), (12), (1), (1)
Host
Rabbit
(68), (26), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(61), (34), (20), (17), (13), (9), (5), (2), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN657764
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Immunogen This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 AA from the Central region of human CENPA.
Clone RB33757
Isotype Ig
Specificity This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human CENPA.
Predicted Reactivity Cow (Bovine),Hamster
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CENPA
Background Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Synonyms: Histone H3-like centromeric protein A,CENPA,
Molecular Weight 15991 DA
Gene ID 1058
NCBI Accession NP_001800, NP_001035891
UniProt P49450
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CENPA Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Centromere Protein A (CENPA) (AA 82-110), (Center) antibody CENPA Antibody (Center) (ABIN657764) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the CENPA antibody detected the CENPA protein (arrow).
Background publications Carroll, Milks, Straight: "Dual recognition of CENP-A nucleosomes is required for centromere assembly." in: The Journal of cell biology, Vol. 189, Issue 7, pp. 1143-55, 2010 (PubMed).

Sekulic, Bassett, Rogers et al.: "The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres." in: Nature, Vol. 467, Issue 7313, pp. 347-51, 2010 (PubMed).

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