Retinoic Acid Receptor, alpha (RARA) (C-Term), (AA 322-349) antibody

Details for Product No. ABIN657770
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Antigen
Synonyms rar-alpha, nr1b1, NR1B1, RAR, Nr1b1, RARalpha1, HS-RARa, rara2a, RAR-ALPHA1
Epitope
C-Term, AA 322-349
(19), (16), (15), (11), (8), (7), (7), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(112), (58), (51), (6), (5), (1), (1), (1)
Host
Rabbit
(80), (32), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(109), (65), (41), (22), (15), (10), (10), (7), (4), (3), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN657770
238.50 $
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Immunogen This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 AA from the C-terminal region of human RARA.
Clone RB33783
Isotype Ig
Specificity This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-379 amino acids from the C-terminal region of human RARA.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RARA
Background This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Synonyms: Retinoic acid receptor alpha,RARA,NR1B1
Molecular Weight 50771 DA
Gene ID 5914
NCBI Accession NP_000955, NP_001138773, NP_001019980
UniProt P10276
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment RARA Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Retinoic Acid Receptor, alpha (RARA) (C-Term), (AA 322-349) antibody Confocal immunofluorescent analysis of RARA Antibody (C-term) (ABIN657770) with MCF-7 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Background publications Chen, Guidez, Rousselot et al.: "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 3, pp. 1178-82, 1994 (PubMed).

Catalano, Dawson, Somana et al.: "The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia." in: Blood, Vol. 110, Issue 12, pp. 4073-6, 2007 (PubMed).

Park, Kim, Um: "A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 34269-78, 2010 (PubMed).

Asleson, Morgan, Smith et al.: "Amplification of the RARA gene in acute myeloid leukemia: significant finding or coincidental observation?" in: Cancer genetics and cytogenetics, Vol. 202, Issue 1, pp. 33-7, 2010 (PubMed).

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