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Details for Product No. ABIN657857

tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 265-290), (Center), (Tyr284) antibody

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Antigen
Synonyms ACK, ACK-1, ACK1, p21cdc42Hs, AW552477, Ack, Cdgip, Pyk1
Epitope
»Alternatives AA 265-290, Center, Tyr284
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN657857
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-290 AA from the Central region of human ACK1.
Clone RB10083
Isotype Ig
Specificity This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the Central region of human ACK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ACK1
Background This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Synonyms: Activated CDC42 kinase 1,10188,ACK1
Molecular Weight 114569 DA
Gene ID 10188
UniProt Q07912, NP_005772.3, NP_001010938.1
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment ACK1 Antibody (Center Y284) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Prieto-Echagüe, Gucwa, Craddock et al.: "Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1." in: The Journal of biological chemistry, Vol. 285, Issue 14, pp. 10605-15, 2010 (PubMed).

Chua, Lim, Tham et al.: "Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells." in: Molecular oncology, Vol. 4, Issue 4, pp. 323-34, 2010 (PubMed).

Mahajan, Mahajan: "Shepherding AKT and androgen receptor by Ack1 tyrosine kinase." in: Journal of cellular physiology, Vol. 224, Issue 2, pp. 327-33, 2010 (PubMed).

Alternatives for antigen "tyrosine Kinase, Non-Receptor, 2 (TNK2)", type "Antibodies"
Hosts (110), (3), (3)
Reactivities (112), (74), (62), (49), (49), (48), (12), (2)
Applications (73), (44), (40), (19), (13), (6), (4), (3), (3), (2), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (18), (16), (12), (12), (7), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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