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Details for Product No. ABIN657957

CUGBP, Elav-Like Family Member 1 (CELF1) (N-Term), (AA 1-30) antibody

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CUGBP, NAB50, CUG-BP, Cugbp1, HNAB50, Brunol2, CUG-BP1, AA407467, D2Wsu101e, 1600010O03Rik, BRUNOL2, CUGBP1, EDEN-BP, NAPOR, hNab50, Bruno-like, brul, cb920, cugbp1, brunol2, cug-bp, cug-bp1, cugbp, c ... show more
»Alternatives N-Term, AA 1-30
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN657957
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This CUGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human CUGBP1.
Clone RB34074
Isotype Ig
Specificity This CUGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CUGBP1.
Predicted Reactivity Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CUGBP1
Background Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: CUGBP Elav-like family member 1,10658,BRUNOL2, CUGBP, CUGBP1, NAB50
Molecular Weight 52063 DA
Gene ID 10658
UniProt NP_001166110.1, NP_001020767.1, NP_941989.1, NP_001166111.1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment CUGBP1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Tsuda, Kuwasako, Takahashi et al.: "Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3." in: Nucleic acids research, Vol. 37, Issue 15, pp. 5151-66, 2009 (PubMed).

Koshelev, Sarma, Price et al.: "Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1." in: Human molecular genetics, Vol. 19, Issue 6, pp. 1066-75, 2010 (PubMed).

Le Tonquèze, Gschloessl, Namanda-Vanderbeken et al.: "Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 884-9, 2010 (PubMed).

Alternatives for antigen "CUGBP, Elav-Like Family Member 1 (CELF1)", type "Antibodies"
Hosts (33), (10)
Reactivities (39), (27), (26), (16), (15), (12), (12), (3), (1), (1)
Applications (32), (11), (11), (10), (9), (9), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (2), (2), (1), (1), (1), (1), (1), (1)