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LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN658023
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Antigen
Epitope
N-Term, AA 1-30
(18), (7), (6), (5), (4), (2), (1), (1)
Reactivity
Human
(89), (16), (15), (13), (13), (12), (3), (1)
Host
Rabbit
(50), (44), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(64), (43), (24), (12), (11), (10), (8), (7), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN658023
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Immunogen This LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human LMO2.
Clone RB33753
Isotype Ig
Specificity This LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LMO2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LMO2
Background LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: Rhombotin-2,LMO2,RBTN2, RBTNL1, RHOM2, TTG2
Molecular Weight 18358 DA
Gene ID 4005
UniProt NP_001135788.1, P25791, NP_001135787.1, NP_005565.2
Research Area Cancer, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment LMO2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) (N-Term), (AA 1-30) antibody LMO2 Antibody (N-term) (ABIN658023) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the LMO2 antibody detected the LMO2 protein (arrow).
Background publications Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).

Durnick, Law, Maurer et al.: "Expression of LMO2 is associated with t(14;18)/IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma." in: American journal of clinical pathology, Vol. 134, Issue 2, pp. 278-81, 2010 (PubMed).

Oram, Thoms, Pridans et al.: "A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients." in: Oncogene, Vol. 29, Issue 43, pp. 5796-808, 2010 (PubMed).

Younes, Beck, Lossos et al.: "Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components." in: The American journal of surgical pathology, Vol. 34, Issue 9, pp. 1266-76, 2010 (PubMed).

Validation Images
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