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ITA6 antibody

Details for Product No. ABIN658988, Supplier: Log in to see
Antigen
Reactivity
Human
15
Host
Mouse
11
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
12
11
9
9
8
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Immunogen ITA6 recombinant protein is used to produce this monoclonal antibody.
Clone 129CT49-6-5
Isotype IgG1, Ig
Specificity ITA6 recombinant protein is used to produce this monoclonal antibody.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Background The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: Integrin alpha-6 light chain, Integrin alpha-6 heavy chain, CD_antigen=CD49f, CD49 antigen-like family member F, VLA-6, Integrin alpha-6,ITGA6
Molecular Weight 126633 DA
Gene ID 3655
UniProt P23229
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:100-16000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ITA6 antibody (ABIN658988) Western blot analysis of anti-ITA6 in HepG2 cell line lysates (35ug/lane). ITA6 (arr...
Immunohistochemistry (IHC) image for anti-ITA6 antibody (ABIN658988) ITA6 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraffi...
Immunofluorescence (IF) image for anti-ITA6 antibody (ABIN658988) Confocal immunofluorescent analysis of ITA6 Antibody with HepG2 cell followed by Ale...
Flow Cytometry (FACS) image for anti-ITA6 antibody (ABIN658988) ITA6 Monoclonal Antibody flow cytometric analysis of HepG2 cells (right histogram) c...
Product cited in: Hu, Fang, Wang, Luk, Thamphiwatana, Dehaini, Nguyen, Angsantikul, Wen, Kroll, Carpenter, Ramesh, Qu, Patel, Zhu, Shi, Hofman, Chen, Gao, Zhang, Chien, Zhang: "Nanoparticle biointerfacing by platelet membrane cloaking." in: Nature, Vol. 526, Issue 7571, pp. 118-21, 2015

Background publications Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010

Kim, Cheng, Hsu, Jin, Kader, Zheng, Isaacs, Xu, Sun: "Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation." in: The Prostate, Vol. 70, Issue 16, pp. 1729-38, 2010

Bouvard, Gafsou, Dizier, Galy-Fauroux, Lokajczyk, Boisson-Vidal, Fischer, Helley: "alpha6-integrin subunit plays a major role in the proangiogenic properties of endothelial progenitor cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 8, pp. 1569-75, 2010

Wang, Fu, Xie, Wang, Chu, Wang, Shen, Wang, Wang, Sun, Lei, Yang, Wu, Foo, Liu, Jin, Huang: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010

Abban, Meneses: "Usage of heparan sulfate, integrins, and FAK in HPV16 infection." in: Virology, Vol. 403, Issue 1, pp. 1-16, 2010