ITA6 antibody

Details for Product No. ABIN658988, Supplier: Log in to see
Clonality (Clone)
Monoclonal ()
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Log in to see
Supplier Product No.
Log in to see
Immunogen ITA6 recombinant protein is used to produce this monoclonal antibody.
Clone 129CT49-6-5
Isotype IgG1, Ig
Specificity ITA6 recombinant protein is used to produce this monoclonal antibody.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Background The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: Integrin alpha-6 light chain, Integrin alpha-6 heavy chain, CD_antigen=CD49f, CD49 antigen-like family member F, VLA-6, Integrin alpha-6,ITGA6
Molecular Weight 126633 DA
Gene ID 3655
UniProt P23229
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:100-16000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ITA6 antibody (ABIN658988) Western blot analysis of anti-ITA6 in HepG2 cell line lysates (35ug/lane). ITA6 (arr...
Immunohistochemistry (IHC) image for anti-ITA6 antibody (ABIN658988) ITA6 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraffi...
Immunofluorescence (IF) image for anti-ITA6 antibody (ABIN658988) Confocal immunofluorescent analysis of ITA6 Antibody with HepG2 cell followed by Ale...
Flow Cytometry (FACS) image for anti-ITA6 antibody (ABIN658988) ITA6 Monoclonal Antibody flow cytometric analysis of HepG2 cells (right histogram) c...
Product cited in: Hu, Fang, Wang, Luk, Thamphiwatana, Dehaini, Nguyen, Angsantikul, Wen, Kroll, Carpenter, Ramesh, Qu, Patel, Zhu, Shi, Hofman, Chen, Gao, Zhang, Chien, Zhang: "Nanoparticle biointerfacing by platelet membrane cloaking." in: Nature, Vol. 526, Issue 7571, pp. 118-21, 2015 (PubMed).

Background publications Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Kim, Cheng, Hsu, Jin, Kader, Zheng, Isaacs, Xu, Sun: "Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation." in: The Prostate, Vol. 70, Issue 16, pp. 1729-38, 2010 (PubMed).

Bouvard, Gafsou, Dizier, Galy-Fauroux, Lokajczyk, Boisson-Vidal, Fischer, Helley: "alpha6-integrin subunit plays a major role in the proangiogenic properties of endothelial progenitor cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 8, pp. 1569-75, 2010 (PubMed).

Wang, Fu, Xie, Wang, Chu, Wang, Shen, Wang, Wang, Sun, Lei, Yang, Wu, Foo, Liu, Jin, Huang: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010 (PubMed).

Abban, Meneses: "Usage of heparan sulfate, integrins, and FAK in HPV16 infection." in: Virology, Vol. 403, Issue 1, pp. 1-16, 2010 (PubMed).

Did you look for something else?