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Details for Product No. ABIN668901

Thyroid Stimulating Hormone Receptor (TSHR) antibody

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Antigen
Synonyms AI481368, hypothroid, hyt, pet, TSHRA, TSH-R, CHNG1, LGR3, hTSHR-I
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine), Pig (Porcine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))
Catalog no. ABIN668901
Quantity 100 µL
Price
242.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen KLH conjugated synthetic peptide derived from human TSHR
Isotype IgG
Cross-Reactivity Rat (Rattus), Chicken, Dog (Canine), Pig (Porcine)
Purification purified by Protein A and peptide affinity chromatography
Alternative Name TSHR
Background The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the auto function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001, Davies et al., 2002). Milliporeメs cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.
Gene ID 7253
Application Notes Recommended dilutions: WB (1:100-500), ELISA (1:500-1000), IHC-P (1:100-500), FACS (1:100-500), IF (cc) (1:100-500)
Restrictions For Research Use only
Format Liquid
Reconstitution If the antibody is in liquid form, no reconstitution needed. Reconstitution is only required for the lyophilized antibody. Please refer to the reconstitution instruction card in the package.
Concentration 1 µg/µL
Buffer Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Storage -20 °C
Storage Comment Store at -20 °C for 12 months
Expiry Date 12 months
Alternatives for antigen "Thyroid Stimulating Hormone Receptor (TSHR)", type "Antibodies"
Hosts (101), (18), (3)
Reactivities (118), (70), (60), (55), (36), (34), (31), (12), (1), (1)
Applications (53), (46), (39), (38), (30), (6), (4), (4), (1), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3)
Epitopes (21), (13), (5), (3), (2), (1), (1)
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