Thyroid Stimulating Hormone Receptor (TSHR) antibody

Details for Product No. ABIN668901
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Antigen
Synonyms CHNG1, LGR3, hTSHR-I, AI481368, hypothroid, hyt, pet, TSHRA, TSH-R
Reactivity
Human, Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine), Pig (Porcine)
(117), (70), (63), (55), (34), (34), (31), (12), (1), (1)
Host
Rabbit
(105), (15), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(52), (51), (50), (37), (21), (6), (5), (4), (1)
Quantity 100 µL
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Catalog No. ABIN668901
242.00 $
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide derived from human TSHR
Isotype IgG
Cross-Reactivity Rat (Rattus), Chicken, Dog (Canine), Pig (Porcine)
Purification purified by Protein A and peptide affinity chromatography
Alternative Name TSHR
Background The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the auto function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001, Davies et al., 2002). Milliporeメs cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.
Gene ID 7253
Application Notes WB (1:100-500),IHC-P (1:100-500),FACS (1:50-200),IF (p) (1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 µg/µL
Buffer Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C for 12 months
Expiry Date 12 months
Supplier Images
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibody Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat Anti-Rabbit IgG at 1: 5000; TMB staining; Read the data in MicroplateReader by 450nm.
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibody (2) Formalin-fixed and paraffin embedded mouse spleen labeled with Rabbit Anti-TSHR Polyclonal Antibody (ABIN668901) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Validation Images
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